OC
|
All-cause dementia (n = 669)
|
Alzheimer’s disease (n = 621)
|
---|
Model 1
|
Model 2
|
Model 1
|
Model 2
|
---|
HR (95%CI)
|
HR (95% CI)
|
HR (95% CI)
|
HR (95% CI)
|
---|
PCB congeners
|
PCB 105
|
0.93 (0.76, 1.13)
|
0.95 (0.77, 1.17)
|
0.91 (0.71, 1.17)
|
0.97 (0.75, 1.26)
|
PCB 118
|
0.94 (0.75, 1.18)
|
0.97 (0.77, 1.23)
|
0.93 (0.71, 1.23)
|
1.00 (0.75, 1.32)
|
PCB 138
|
0.92 (0.73, 1.16)
|
0.95 (0.76, 1.20)
|
0.96 (0.71, 1.29)
|
0.99 (0.74, 1.34)
|
PCB 153
|
0.95 (0.73, 1.24)
|
1.00 (0.77, 1.31)
|
0.94 (0.68, 1.31)
|
0.99 (0.71, 1.38)
|
PCB 156
|
1.16 (0.87, 1.55)
|
1.23 (0.91, 1.65)
|
1.09 (0.76,1.54)
|
1.14 (0.79, 1.65)
|
PCB 163
|
1.03 (0.79, 1.34)
|
1.09 (0.83, 1.42)
|
1.01 (0.73, 1.40)
|
1.08 (0.77, 1.50)
|
PCB 170
|
1.07 (0.83, 1.37)
|
1.11 (0.87, 1.43)
|
1.03 (0.76, 1.40)
|
1.08 (0.78, 1.48)
|
PCB 180
|
1.02 (0.80, 1.31)
|
1.07 (0.84, 1.37)
|
0.98 (0.73, 1.33)
|
1.03 (0.75, 1.41)
|
PCB 183
|
0.90 (0.72, 1.13)
|
0.94 (0.75, 1.17)
|
0.91 (0.69, 1.21)
|
0.94 (0.70, 1.25)
|
PCB 187
|
0.93 (0.75, 1.16)
|
0.97 (0.78, 1.22)
|
0.90 (0.68, 1.18)
|
0.95 (0.72, 1.26)
|
OC pesticides
|
β-HCH
|
1.17 (0.95, 1.46)
|
1.18 (0.95, 1.47)
|
1.20 (0.90, 1.58)
|
1.16 (0.88, 1.54)
|
HCB
|
0.97 (0.79, 1.20)
|
1.01 (0.81, 1.25)
|
1.06 (0.81, 1.38)
|
1.14 (0.87, 1.50)
|
Oxychlordane
|
1.07 (0.80, 1.43)
|
1.13 (0.83, 1.53)
|
1.22 (0.85, 1.76)
|
1.33 (0.91, 1.94)
|
cis-Nonachlor
|
0.94 (0.75, 1.17)
|
0.99 (0.79, 1.24)
|
0.95 (0.73, 1.24)
|
1.04 (0.79, 1.38)
|
trans-Nonachlor
|
0.98 (0.74, 1.28)
|
1.03 (0.78, 1.36)
|
1.02 (0.73, 1.43)
|
1.10 (0.78, 1.55)
|
p,p’-DDT
|
1.03 (0.86, 1.23)
|
1.04 (0.87, 1.26)
|
1.02 (0.81, 1.28)
|
1.08 (0.86, 1.36)
|
p,p’-DDE
|
0.94 (0.81, 1.10)
|
0.96 (0.82, 1.12)
|
0.99 (0.81, 1.21)
|
1.01 (0.82, 1.23)
|
- Note: AD Alzheimer’s disease, BMI body mass index, β-HCH beta hexachlorocyclohexane, HCB hexaclorobenzene, OC organochlorine, HR Hazards ratio, PCBs polychlorinated biphenyl, p,p’-DDT, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane, p,p’-DDE, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene
- Model 1 was adjusted for total lipids and age as time scale, sex, education, and ApoE4
- Model 2 was additionally adjusted for BMI, smoking, alcohol drinking, residence area, vascular score, mercury, lead, cooper and zinc