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Table 3 HRs for all-cause dementia and AD per 1-unit log increase in plasma PCB and OC pesticide concentrations (μg/L)

From: Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging

OC

All-cause dementia (n = 669)

Alzheimer’s disease (n = 621)

Model 1

Model 2

Model 1

Model 2

HR (95%CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

PCB congeners

 PCB 105

0.93 (0.76, 1.13)

0.95 (0.77, 1.17)

0.91 (0.71, 1.17)

0.97 (0.75, 1.26)

 PCB 118

0.94 (0.75, 1.18)

0.97 (0.77, 1.23)

0.93 (0.71, 1.23)

1.00 (0.75, 1.32)

 PCB 138

0.92 (0.73, 1.16)

0.95 (0.76, 1.20)

0.96 (0.71, 1.29)

0.99 (0.74, 1.34)

 PCB 153

0.95 (0.73, 1.24)

1.00 (0.77, 1.31)

0.94 (0.68, 1.31)

0.99 (0.71, 1.38)

 PCB 156

1.16 (0.87, 1.55)

1.23 (0.91, 1.65)

1.09 (0.76,1.54)

1.14 (0.79, 1.65)

 PCB 163

1.03 (0.79, 1.34)

1.09 (0.83, 1.42)

1.01 (0.73, 1.40)

1.08 (0.77, 1.50)

 PCB 170

1.07 (0.83, 1.37)

1.11 (0.87, 1.43)

1.03 (0.76, 1.40)

1.08 (0.78, 1.48)

 PCB 180

1.02 (0.80, 1.31)

1.07 (0.84, 1.37)

0.98 (0.73, 1.33)

1.03 (0.75, 1.41)

 PCB 183

0.90 (0.72, 1.13)

0.94 (0.75, 1.17)

0.91 (0.69, 1.21)

0.94 (0.70, 1.25)

 PCB 187

0.93 (0.75, 1.16)

0.97 (0.78, 1.22)

0.90 (0.68, 1.18)

0.95 (0.72, 1.26)

OC pesticides

 β-HCH

1.17 (0.95, 1.46)

1.18 (0.95, 1.47)

1.20 (0.90, 1.58)

1.16 (0.88, 1.54)

 HCB

0.97 (0.79, 1.20)

1.01 (0.81, 1.25)

1.06 (0.81, 1.38)

1.14 (0.87, 1.50)

 Oxychlordane

1.07 (0.80, 1.43)

1.13 (0.83, 1.53)

1.22 (0.85, 1.76)

1.33 (0.91, 1.94)

 cis-Nonachlor

0.94 (0.75, 1.17)

0.99 (0.79, 1.24)

0.95 (0.73, 1.24)

1.04 (0.79, 1.38)

 trans-Nonachlor

0.98 (0.74, 1.28)

1.03 (0.78, 1.36)

1.02 (0.73, 1.43)

1.10 (0.78, 1.55)

 p,p’-DDT

1.03 (0.86, 1.23)

1.04 (0.87, 1.26)

1.02 (0.81, 1.28)

1.08 (0.86, 1.36)

 p,p’-DDE

0.94 (0.81, 1.10)

0.96 (0.82, 1.12)

0.99 (0.81, 1.21)

1.01 (0.82, 1.23)

  1. Note: AD Alzheimer’s disease, BMI body mass index, β-HCH beta hexachlorocyclohexane, HCB hexaclorobenzene, OC organochlorine, HR Hazards ratio, PCBs polychlorinated biphenyl, p,p’-DDT, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane, p,p’-DDE, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene
  2. Model 1 was adjusted for total lipids and age as time scale, sex, education, and ApoE4
  3. Model 2 was additionally adjusted for BMI, smoking, alcohol drinking, residence area, vascular score, mercury, lead, cooper and zinc
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Environmental Health

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