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Table 4 Estimated coefficients of plasma log-transformed PCB and OC pesticide concentrations (μg/L) in relation to 3MS scores

From: Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging

OC concentrations

Model 1

Model 2

β

SE

P-value

β

SE

P-value

PCB congeners

 PCB 105

−0.811

0.509

0.111

−0.780

0.544

0.151

 PCB 118

−1.225

0.581

0.035

−1.207

0.611

0.048

 PCB 138

−1.219

0.626

0.052

−1.223

0.644

0.058

 PCB 153

−1.387

0.705

0.049

− 1.449

0.727

0.046

 PCB 156

−1.509

0.755

0.046

−1.586

0.780

0.042

 PCB 163

−1.501

0.699

0.032

−1.602

0.724

0.027

 PCB 170

−0.830

0.691

0.230

−0.908

0.708

0.200

 PCB 180

−0.521

0.688

0.448

−0.611

0.707

0.390

 PCB 183

−0.948

0.611

0.121

−0.968

0.629

0.124

 PCB 187

−0.149

0.580

0.797

−0.215

0.601

0.721

OC pesticides

 β-HCH

−0.751

0.590

0.203

−0.699

0.606

0.249

 HCB

−0.737

0.519

0.156

−0.644

0.541

0.233

 Oxychlordane

−0.602

0.803

0.454

−0.540

0.824

0.512

cis-nonachlor

−0.044

0.585

0.940

+ 0.038

0.627

0.952

trans-Nonachlor

−0.351

0.714

0.623

−0.332

0.742

0.655

p,p’-DDT

−1.717

0.468

< 0.001

−1.693

0.487

< 0.001

p,p’-DDE

−1.554

0.414

< 0.001

−1.578

0.422

< 0.001

  1. Note: 3MS Modified Mini-Mental State Examination, β beta, BMI body mass index, β-HCH beta hexachlorocyclohexane, HCB hexaclorobenzene, OC organochlorine, PCBs polychlorinated biphenyls, p,p’-DDT, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane; p,p’-DDE, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, SE standard error
  2. Repeated measures regression models with unstructured correlation matrix
  3. Model 1 was adjusted for total lipids and CSHA phase, age, sex, education, and ApoE4
  4. Model 2 was additionally adjusted for BMI, smoking, alcohol drinking, residence area, vascular score, copper, lead, mercury and zinc