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Table 4 Estimated coefficients of plasma log-transformed PCB and OC pesticide concentrations (μg/L) in relation to 3MS scores

From: Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging

OC concentrations Model 1 Model 2
β SE P-value β SE P-value
PCB congeners
 PCB 105 −0.811 0.509 0.111 −0.780 0.544 0.151
 PCB 118 −1.225 0.581 0.035 −1.207 0.611 0.048
 PCB 138 −1.219 0.626 0.052 −1.223 0.644 0.058
 PCB 153 −1.387 0.705 0.049 − 1.449 0.727 0.046
 PCB 156 −1.509 0.755 0.046 −1.586 0.780 0.042
 PCB 163 −1.501 0.699 0.032 −1.602 0.724 0.027
 PCB 170 −0.830 0.691 0.230 −0.908 0.708 0.200
 PCB 180 −0.521 0.688 0.448 −0.611 0.707 0.390
 PCB 183 −0.948 0.611 0.121 −0.968 0.629 0.124
 PCB 187 −0.149 0.580 0.797 −0.215 0.601 0.721
OC pesticides
 β-HCH −0.751 0.590 0.203 −0.699 0.606 0.249
 HCB −0.737 0.519 0.156 −0.644 0.541 0.233
 Oxychlordane −0.602 0.803 0.454 −0.540 0.824 0.512
cis-nonachlor −0.044 0.585 0.940 + 0.038 0.627 0.952
trans-Nonachlor −0.351 0.714 0.623 −0.332 0.742 0.655
p,p’-DDT −1.717 0.468 < 0.001 −1.693 0.487 < 0.001
p,p’-DDE −1.554 0.414 < 0.001 −1.578 0.422 < 0.001
  1. Note: 3MS Modified Mini-Mental State Examination, β beta, BMI body mass index, β-HCH beta hexachlorocyclohexane, HCB hexaclorobenzene, OC organochlorine, PCBs polychlorinated biphenyls, p,p’-DDT, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane; p,p’-DDE, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, SE standard error
  2. Repeated measures regression models with unstructured correlation matrix
  3. Model 1 was adjusted for total lipids and CSHA phase, age, sex, education, and ApoE4
  4. Model 2 was additionally adjusted for BMI, smoking, alcohol drinking, residence area, vascular score, copper, lead, mercury and zinc