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Table 3 DNA damage in cord blood of newborns exposed to arsenic in utero

From: Correction to: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

Types of DNA damage

Maternal arsenic exposure by toenail As

FDR-adjusted p-valuea

Low (< 0.5 Ī¼g/g)

Medium (0.5-1 Ī¼g/g)

High (>1 Ī¼g/g)

8-OHdG (ng/mL)

0.24Ā±0.01b

0.26Ā±0.01

0.28Ā±0.01**

0.010

0.24 (0.13-0.44)c

0.26 (0.18-0.49)

0.26 (0.19-0.55)

Ā 

(n=81)

(n=52)

(n=61)

Ā 

8-Nitroguanine (ng/mL)

157.66Ā±13.85

183.21Ā±17.90

229.94Ā±23.34*

0.032

117.20 (13.59-426.51)

154.99 (22.51-540.60)

178.77 (26.73-831.84)

Ā 

(n=78)

(n=53)

(n=58)

Ā 

DNA strand breaks

Tail length (Ī¼m)

2.37Ā±0.08

2.81Ā±0.10**

3.04Ā±0.09***

0.000

2.38 (0.65-4.11)

2.74 (1.13-4.03)

2.98 (1.69-4.92)

Ā 

(n=73)

(n=48)

(n=54)

Ā 

Olive tail moment (Ī¼m)d

0.20Ā±0.01

0.24Ā±0.01**

0.27Ā±0.01***

0.000

0.19 (0.07-0.39)

0.22 (0.07-0.44)

0.26 (0.11-0.49)

Ā 

(n=73)

(n=48)

(n=54)

Ā 

%DNA in tail

1.36Ā±0.06

1.62Ā±0.08*

1.94Ā±0.10***, ##

0.000

1.28 (0.53-3.00)

1.51 (0.37-2.88)

1.82 (0.48-4.05)

Ā 

(n=73)

(n=48)

(n=54)

Ā 
  1. aThe raw p-values were subjected to multiple testing correction using FDR-adjusted p-value; Statistically significant difference among groups at p <0.05 by One-way ANOVA are highlighted in bold
  2. Values are expressed as mean Ā± SE (b) and Median (minimum - maximum) (c)
  3. *, **, *** Statistically significant difference from corresponding low- exposed group at p < 0.05, < 0.01 and < 0.001, respectively by Mann-Whitney U test
  4. ## Statistically significant difference from corresponding medium-exposed group at p< 0.01 by Mann-Whitney U test
  5. d Olive tail moment is the product of the tail length and the fraction of total DNA in the tail.