Types of DNA damage | Maternal arsenic exposure by toenail As | FDR-adjusted p-valuea | ||
---|---|---|---|---|
Low (< 0.5 Ī¼g/g) | Medium (0.5-1 Ī¼g/g) | High (>1 Ī¼g/g) | ||
8-OHdG (ng/mL) | 0.24Ā±0.01b | 0.26Ā±0.01 | 0.28Ā±0.01** | 0.010 |
0.24 (0.13-0.44)c | 0.26 (0.18-0.49) | 0.26 (0.19-0.55) | Ā | |
(n=81) | (n=52) | (n=61) | Ā | |
8-Nitroguanine (ng/mL) | 157.66Ā±13.85 | 183.21Ā±17.90 | 229.94Ā±23.34* | 0.032 |
117.20 (13.59-426.51) | 154.99 (22.51-540.60) | 178.77 (26.73-831.84) | Ā | |
(n=78) | (n=53) | (n=58) | Ā | |
DNA strand breaks | ||||
Tail length (Ī¼m) | 2.37Ā±0.08 | 2.81Ā±0.10** | 3.04Ā±0.09*** | 0.000 |
2.38 (0.65-4.11) | 2.74 (1.13-4.03) | 2.98 (1.69-4.92) | Ā | |
(n=73) | (n=48) | (n=54) | Ā | |
Olive tail moment (Ī¼m)d | 0.20Ā±0.01 | 0.24Ā±0.01** | 0.27Ā±0.01*** | 0.000 |
0.19 (0.07-0.39) | 0.22 (0.07-0.44) | 0.26 (0.11-0.49) | Ā | |
(n=73) | (n=48) | (n=54) | Ā | |
%DNA in tail | 1.36Ā±0.06 | 1.62Ā±0.08* | 1.94Ā±0.10***, ## | 0.000 |
1.28 (0.53-3.00) | 1.51 (0.37-2.88) | 1.82 (0.48-4.05) | Ā | |
(n=73) | (n=48) | (n=54) | Ā |