Skip to main content

Table 3 DNA damage in cord blood of newborns exposed to arsenic in utero

From: Correction to: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

Types of DNA damageMaternal arsenic exposure by toenail AsFDR-adjusted p-valuea
Low (< 0.5 μg/g)Medium (0.5-1 μg/g)High (>1 μg/g)
8-OHdG (ng/mL)0.24±0.01b0.26±0.010.28±0.01**0.010
0.24 (0.13-0.44)c0.26 (0.18-0.49)0.26 (0.19-0.55) 
(n=81)(n=52)(n=61) 
8-Nitroguanine (ng/mL)157.66±13.85183.21±17.90229.94±23.34*0.032
117.20 (13.59-426.51)154.99 (22.51-540.60)178.77 (26.73-831.84) 
(n=78)(n=53)(n=58) 
DNA strand breaks
Tail length (μm)2.37±0.082.81±0.10**3.04±0.09***0.000
2.38 (0.65-4.11)2.74 (1.13-4.03)2.98 (1.69-4.92) 
(n=73)(n=48)(n=54) 
Olive tail moment (μm)d0.20±0.010.24±0.01**0.27±0.01***0.000
0.19 (0.07-0.39)0.22 (0.07-0.44)0.26 (0.11-0.49) 
(n=73)(n=48)(n=54) 
%DNA in tail1.36±0.061.62±0.08*1.94±0.10***, ##0.000
1.28 (0.53-3.00)1.51 (0.37-2.88)1.82 (0.48-4.05) 
(n=73)(n=48)(n=54) 
  1. aThe raw p-values were subjected to multiple testing correction using FDR-adjusted p-value; Statistically significant difference among groups at p <0.05 by One-way ANOVA are highlighted in bold
  2. Values are expressed as mean ± SE (b) and Median (minimum - maximum) (c)
  3. *, **, *** Statistically significant difference from corresponding low- exposed group at p < 0.05, < 0.01 and < 0.001, respectively by Mann-Whitney U test
  4. ## Statistically significant difference from corresponding medium-exposed group at p< 0.01 by Mann-Whitney U test
  5. d Olive tail moment is the product of the tail length and the fraction of total DNA in the tail.