| Types of DNA damage | Maternal arsenic exposure by toenail As | FDR-adjusted p-valuea |
|---|
| Low (< 0.5 μg/g) | Medium (0.5-1 μg/g) | High (>1 μg/g) |
|---|
| 8-OHdG (ng/mL) | 0.24±0.01b | 0.26±0.01 | 0.28±0.01** | 0.010 |
| 0.24 (0.13-0.44)c | 0.26 (0.18-0.49) | 0.26 (0.19-0.55) | |
| (n=81) | (n=52) | (n=61) | |
| 8-Nitroguanine (ng/mL) | 157.66±13.85 | 183.21±17.90 | 229.94±23.34* | 0.032 |
| 117.20 (13.59-426.51) | 154.99 (22.51-540.60) | 178.77 (26.73-831.84) | |
| (n=78) | (n=53) | (n=58) | |
| DNA strand breaks |
| Tail length (μm) | 2.37±0.08 | 2.81±0.10** | 3.04±0.09*** | 0.000 |
| 2.38 (0.65-4.11) | 2.74 (1.13-4.03) | 2.98 (1.69-4.92) | |
| (n=73) | (n=48) | (n=54) | |
| Olive tail moment (μm)d | 0.20±0.01 | 0.24±0.01** | 0.27±0.01*** | 0.000 |
| 0.19 (0.07-0.39) | 0.22 (0.07-0.44) | 0.26 (0.11-0.49) | |
| (n=73) | (n=48) | (n=54) | |
| %DNA in tail | 1.36±0.06 | 1.62±0.08* | 1.94±0.10***, ## | 0.000 |
| 1.28 (0.53-3.00) | 1.51 (0.37-2.88) | 1.82 (0.48-4.05) | |
| (n=73) | (n=48) | (n=54) | |
- aThe raw p-values were subjected to multiple testing correction using FDR-adjusted p-value; Statistically significant difference among groups at p <0.05 by One-way ANOVA are highlighted in bold
- Values are expressed as mean ± SE (b) and Median (minimum - maximum) (c)
- *, **, *** Statistically significant difference from corresponding low- exposed group at p < 0.05, < 0.01 and < 0.001, respectively by Mann-Whitney U test
- ## Statistically significant difference from corresponding medium-exposed group at p< 0.01 by Mann-Whitney U test
- d Olive tail moment is the product of the tail length and the fraction of total DNA in the tail.
