Neurocognitive impact of metal exposure and social stressors among schoolchildren in Taranto, Italy

Table 6 Linear mixed effect model testing SES and biomarkers interaction term association with neurocognitive outcomes

	SES Mid vs Low	SES High vs Low	log(BPb)	SES Mid vs Low X log(BPb)	SES High vs Low X log(BPb)
IQ	1.0 (−2.8, 4.9)	5.2^a (0.3, 10.4)	−2.7 (−5.6, 0.2)	2.2 (− 1.7, 5.8)	1.8 (− 2.8, 6.4)
GAI	1.1 (− 2.9, 5.6)	6.3^a (1.0, 11.8)	− 3.5^a (− 6.7, − 0.3)	2.8 (− 1.1, 7.3)	2.5 (− 2.0, 7.3)
CPI	0.3 (− 3.6, 4.3)	2.0 (− 2.9, 7.1)	−3.5^a (− 6.7, − 0.7)	4.1^a (0.2, 7.9)	1.6 (−2.9, 6.0)
WMI	0.9 (− 3.0, 4.9)	6.1^a (1.3, 11.0)	− 4.0^a (− 6.9, − 1.1)	4.5^a (0.8, 8.3)	4.9^a (0.4, 9.4)
PSI	2.0 (−2.0, 5.9)	− 0.5 (− 5.9, 4.1)	− 0.8 (− 3.9, 2.3)	1.5 (− 2.8, 5.3)	0.6 (−3.6, 5.2)
PRI	0.01 (− 4.0, 3.7)	2.1 (− 2.8, 7.4)	− 1.3 (− 4.3, 1.8)	0.4 (− 3.4, 4.2)	2.2 (−2.3, 7.0)
VCI	2.4 (−1.8, 6.7)	8.2^a (1.9, 14.4)	−2.2 (− 5.3, 0.9)	− 0.2 (− 4.3, 4.0)	2.7 (− 2.5, 7.9)

Notes: Linear mixed effect model β coefficients and 95% confidence intervals (CI) for SES, BPb concentration and the interaction term between SES and BPb for the association with IQ and its sub-scores. All the models were adjusted for age, sex, maternal SPM, HOME total score, and distance from the point source
SES Socio-economic status, BPb blood lead, IQ Intellectual Quotient, VCI Verbal Comprehension Index, PRI Visual-Perceptual Reasoning Index, WMI Working Memory Index, PSI Processing Speed Index, GAI General Ability Index, CPI Cognitive Proficiency Index
^aStatistically significant difference from 0

ISSN: 1476-069X