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Table 3 CYP1A1 hypomethylation mediated the effect of smoking and 1-OHP co-exposure on high 8-OHdG

From: CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

Co-exposure

Total effect

Direct effect

Proportion mediated by CYP1A1 hypomethylation

P value

Smoking and1-OHP

1.03 (1.00–1.06)

1.02 (1.00–1.05)

13.6% (2.6–47.9%)

0.047

  1. Covariates in the SAS macro include sex, age,years of working, drinking status, education and central heating
  2. aTotal effects of smoking and 1-OHP co-exposure on high 8-OHdGwere estimated without adjusting for CYP1A1hypomethylation
  3. bDirect effects of smoking and 1-OHP co-exposure on high 8-OHdG were estimated with adjusting for CYP1A1hypomethylation
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Environmental Health

ISSN: 1476-069X