Skip to main content

Advertisement

Table 4 Pooled cohort study of asbestos cement workers in Italy. Cause specific mortality by gender and time since first exposure for selected diseases

From: Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy

TIME SINCE FIRST EXPOSURE
MALES 0–9 10–19 20–29 30–39 40–49 50+
Causes of death n SMR (95% CI) n SMR (95% CI) n SMR (95% CI) n SMR (95% CI) n SMR (95% CI) n SMR (95% CI)
All causes 137 0.89 (0.75–1.05) 514 1.05 (0.96–1.14) 1099 1.14** (1.08–1.21) 1601 1.29** (1.22–1.35) 1463 1.31** (1.25–1.38) 777 1.31** (1.22–1.40)
Malignant neoplasm 32 0.69* (0.47–0.97) 173 1.02 (0.87–1.18) 469 1.32** (1.20–1.44) 752 1.63** (1.51–1.75) 660 1.70** (1.58–1.84) 256 1.52** (1.34–1.72)
MN stomach 4 0.72 (0.20–1.85) 16 0.84 (0.48–1.36) 25 0.72 (0.47–1.06) 53 1.36* (1.02–1.78) 30 1.03 (0.70–1.47) 8 0.66 (0.29–1.30)
MN colon 3 1.25 (0.26–3.64) 7 0.77 (0.31–1.58) 19 0.94 (0.57–1.47) 32 1.09 (0.75–1.54) 34 1.21 (0.84–1.70) 22 1.66* (1.04–2.51)
MN rectum 4 0.82 (0.22–2.10) 3 0.29* (0.06–0.85) 11 0.81 (0.41–1.46) 16 1.45 (0.83–2.36) 6 1.22 (0.45–2.65)
MN peritoneum 10 5.77** (2.77–10.61) 23 10.38** (6.58–15.57) 46 31.62** (23.15–42.18) 23 47.13** (29.87–70.71)
MN respiratory organs 16 0.97 (0.55–1.57) 80 1.27* (1.00–1.58) 237 1.80** (1.58–2.04) 410 2.50** (2.26–2.75) 321 2.51** (2.25–2.80) 120 2.45** (2.03–2.93)
MN larynx 1 0.57 (0.01–3.16) 4 0.62 (0.17–1.60) 11 0.96 (0.48–1.71) 9 0.77 (0.35–1.47) 20 2.63** (1.61–4.06) 5 1.73 (0.56–4.03)
MN lung 13 0.92 (0.49–1.57) 62 1.13 (0.87–1.45) 185 1.59 ** (1.37–1.84) 289 1.97** (1.75–2.21) 198 1.72** (1.49–1.98) 73 1.67** (1.31–2.10)
MN pleura 13 13.12** (6.99–22.44) 39 14.98** (10.65–20.48) 109 27.00** (22.17–32.57) 103 25.41** (20.74–30.82) 41 23.67** (16.98–32.11)
Respiratory diseases 4 0.75 (0.20–1.92) 28 1.25 (0.83–1.81) 98 1.82** (1.48–2.22) 188 2.30** (1.98–2.65) 202 2.31** (2.00–2.65) 159 2.79** (2.38–3.26)
Bronchitis, emphysema, asthma 2 0.85 (0.10–3.09) 7 0.60 (0.24–1.24) 36 1.26 (0.88–1.74) 47 1.19 (0.87–1.58) 35 1.17 (0.81–1.63) 23 1.52 (0.96–2.28)
Asbestosis 9 241.37** (110.36–458.20) 41 442.77** (317.74–600.67) 94 469.65** (379.53–574.73) 106 491.34** (402.26–594.27) 98 729.36** (592.13–888.86)
Cardiovascular diseases 30 0.73 (0.49–1.04) 131 0.82* (0.69–0.98) 282 0.83** (0.74–0.93) 415 0.91 (0.83–1.00) 368 0.88* (0.80–0.98) 218 0.89 (0.77–1.01)
Digestive diseases 14 0.97 (0.53–1.63) 35 0.76 (0.53–1.06) 73 0.99 (0.78–1.25) 77 1.06 (0.84–1.33) 52 1.01 (0.75–1.32) 25 1.06 (0.69–1.56)
Accidents and violence 35 1.19 (0.83–1.66) 55 1.15 (0.87–1.50) 44 0.78 (0.57–1.04) 38 0.77 (0.55–1.06) 25 0.73 (0.47–1.08) 24 1.38 (0.88–2.05)
FEMALES 0–9 10–19 20–29 30–39 40–49 50+
Causes of death n SMR (95% CI) n SMR (95% CI) n SMR (95% CI) n SMR (95% CI) n SMR (95% CI) n SMR (95% CI)
All causes 9 1.26 (0.58–2.40) 29 1.06 (0.71–1.52) 83 1.09 (0.87–1.36) 196 1.37** (1.18–1.57) 266 1.26** (1.11–1.42) 452 1.48** (1.35–1.62)
Malignant neoplasm 1 0.33 (0.01–1.84) 17 1.38 (0.80–2.21) 46 1.42* (1.04–1.89) 91 1.67** (1.34–2.05) 115 1.70** (1.41–2.05) 144 1.97** (1.66–2.32)
MN stomach 3 3.28 (0.68–9.57) 2 0.84 (0.10–3.04) 7 1.82 (0.73–3.76) 5 1.11 (0.36–2.59) 5 1.03 (0.34–2.41)
MN colon 1 1.23 (0.03–6.85) 1 0.43 (0.01–2.42) 7 1.68 (0.68–3.46) 8 1.40 (0.60–2.75) 9 1.30 (0.60–2.48)
MN rectum 2 1.13 (0.14–4.10) 4 1.89 (0.51–4.83) 5 2.13 (0.69–2.48)
MN peritoneum 1 3.34 (0.08–18.60) 1 2.05 (0.05–11.40) 7 10.96** (4.41–22.59) 22 46.17** (28.94–69.91)
MN respiratory organs 4 4.09* (1.11–10.47) 11 3.61** (1.80–6.46) 36 6.30** (4.41–8.72) 39 5.04** (3.59–6.89) 40 4.85** (3.46–6.60)
MN larynx 1 6.31 (0.16–35.16) 1 6.25 (0.16–34.80)
MN lung 2 2.38 (0.29–8.59) 5 1.87 (0.61–4.36) 11 2.18* (1.09–3.90) 10 1.46 (0.70–2.69) 10 1.38 (0.66–2.54)
MN pleura 2 36.54** (4.42–131.98) 6 35.46** (13.01–77.17) 23 63.45** (40.22–95.20) 29 52.38** (35.08–75.23) 29 41.48** (27.78–59.58)
MN ovary 2 1.04 (0.13–3.74) 4 1.27 (0.35–3.25) 4 1.14 (0.31–2.93) 9 2.83* (1.30–5.38)
Respiratory diseases 1 0.39 (0.01–2.15) 14 2.46** (1.34–4.12) 19 1.88* (1.13–2.94) 58 3.23** (2.46–4.18)
Bronchitis, emphysema, asthma 6 2.73* (1.00–5.95) 2 0.65 (0.08–2.33) 8 2.05 (0.88–4.04)
Asbestosis 5 727.34** (236.09–1697.31) 11 880.35** (439.46–1575.19) 35 1331.02** (927.11–1851.15)
Cardiovascular diseases 3 2.29 (0.47–6.70) 4 0.60 (0.16–1.55) 11 0.48** (0.24–0.85) 60 1.17 (0.89–1.50) 80 0.95 (0.75–1.18) 149 1.08 (0.91–1.27)
Digestive diseases 1 0.51 (0.01–2.84) 7 1.34 (0.54–2.78) 10 1.17 (0.56–2.16) 16 1.47 (0.84–2.38) 11 0.82 (0.41–1.46)
Accidents and violence 5 4.41* (1.43–10.30) 4 1.70 (0.46–4.34) 5 1.23 (0.40–2.86) 6 1.11 (0.41–2.41) 6 0.91 (0.33–1.97) 9 0.99 (0.45–1.88)
  1. OBS observed, EXP expected, SMR standardized mortality ratio, CI confidence interval. * p < 0.05; ** p < 0.01