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Table 3 Mean (standard error of the mean)) of urinary nitrate, 1-Methylhistidine, and 3-Methylhistidineexcretion, faecal water apparent nitroso compounds (ATNC) and Comet assay tail intensity levels for the unprocessed white and processed red meat group at baseline and after the low and high-nitrate (NO3) drinking water periods

From: Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers

  Unprocessed white Meat Processed red Meat
Baseline Low NO3 drinking water levels
(<  1.5 mg/L)
High NO3 drinking water levels
(ADI- levels)
pt-test Baseline Low NO3 drinking water levels
(<  1.5 mg/L)
High NO3 drinking water levels
(ADI-levels)
pt-test
Urinary NO3 [μmol/day] 740 (218) 375 (67) 1071 (111) < 0.001a
0.19b
0.13c
714 (110) 634 (255) 1572 (295) < 0.05a
0.05b
0.78c
Urinary 1-Methylhistidine [μmol/day] 25.1 (7.0) 15.8 (3.3) 18.6 (5.0) 0.64a
0.46b
0.25c
20.7 (3.5) 29.1 (7.0) 31.2 (5.5) 0.81a
< 0.05b
0.30c
Urinary 3-Methylhistidine [μmol/day] 63.9 (36.9) 256.6 (50.9) 296.8 (98.4) 0.72a
< 0.01b,c
73.4 (23.0) 26.2 (11.3) 11.8 (2.5) 0.24a
< 0.05b
0.09c
Faecal water ATNC [μmol/L] 15.8 (3.2) 14.7 (3.8) 30.2 (6.0) < 0.05a
0.05b
0.83c
16.7 (3.0) 17.6 (3.2) 44.2 (7.7) < 0.01a,b
0.84c
Cometd 100.0 (0.0) 157.3 (37.9) 152.9 (50.4) 0.89a
0.35b
0.16c
100.0 (0.0) 173.2 (28.7) 138.0 (23.4) 0.35a
0.21b
< 0.05c
  1. a) difference between low NO3 and high NO3 drinking water period; b) difference between high NO3 drinking water period and baseline; c) difference between low NO3 drinking water period and baseline
  2. dtail intensity levels relative to baseline