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Table 3 Mean (standard error of the mean)) of urinary nitrate, 1-Methylhistidine, and 3-Methylhistidineexcretion, faecal water apparent nitroso compounds (ATNC) and Comet assay tail intensity levels for the unprocessed white and processed red meat group at baseline and after the low and high-nitrate (NO3) drinking water periods

From: Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers

 

Unprocessed white Meat

Processed red Meat

Baseline

Low NO3 drinking water levels

(<  1.5 mg/L)

High NO3 drinking water levels

(ADI- levels)

pt-test

Baseline

Low NO3 drinking water levels

(<  1.5 mg/L)

High NO3 drinking water levels

(ADI-levels)

pt-test

Urinary NO3 [μmol/day]

740 (218)

375 (67)

1071 (111)

< 0.001a

0.19b

0.13c

714 (110)

634 (255)

1572 (295)

< 0.05a

0.05b

0.78c

Urinary 1-Methylhistidine [μmol/day]

25.1 (7.0)

15.8 (3.3)

18.6 (5.0)

0.64a

0.46b

0.25c

20.7 (3.5)

29.1 (7.0)

31.2 (5.5)

0.81a

< 0.05b

0.30c

Urinary 3-Methylhistidine [μmol/day]

63.9 (36.9)

256.6 (50.9)

296.8 (98.4)

0.72a

< 0.01b,c

73.4 (23.0)

26.2 (11.3)

11.8 (2.5)

0.24a

< 0.05b

0.09c

Faecal water ATNC [μmol/L]

15.8 (3.2)

14.7 (3.8)

30.2 (6.0)

< 0.05a

0.05b

0.83c

16.7 (3.0)

17.6 (3.2)

44.2 (7.7)

< 0.01a,b

0.84c

Cometd

100.0 (0.0)

157.3 (37.9)

152.9 (50.4)

0.89a

0.35b

0.16c

100.0 (0.0)

173.2 (28.7)

138.0 (23.4)

0.35a

0.21b

< 0.05c

  1. a) difference between low NO3 and high NO3 drinking water period; b) difference between high NO3 drinking water period and baseline; c) difference between low NO3 drinking water period and baseline
  2. dtail intensity levels relative to baseline