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Table 3 Associations between prenatal maternal urinary BPA and white matter tract parameters by child sex

From: Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children

Tract DTI Parameter All Children
B (95% CI)
(N = 98) 		Boys
B (95% CI)
(N = 48) 		Girls
B (95% CI)
(N = 50) 		Tract x Sex
p-value
Left Cingulum FA 0.007 (− 0.213, 0.226) 0.016 (− 0.240, 0.266) − 0.031 (− 0.435, 0.360) 0.738
MD 0.056 (− 0.156, 0.269) 0.087 (− 0.203, 0.367) − 0.022 (− 0.367, 0.323) 0.780
Right Cingulum FA 0.133 (− 0.089, 0.354) 0.194 (− 0.123, 0.470) 0.077 (− 0.250, 0.427) 0.407
MD 0.090 (− 0.116, 0.295) 0.119 (− 0.163, 0.372) 0.026 (− 0.313, 0.369) 0.646
CC Body FA 0.034 (− 0.195, 0.262) − 0.146 (− 0.390, 0.140) 0.286 (− 0.063, 0.740) 0.434
MD 0.041 (− 0.172, 0.254) 0.043 (− 0.258, 0.340) − 0.001 (− 0.326, 0.325) 0.539
CC Genu FA 0.051 (− 0.174, 0.276) − 0.076 (− 0.322, 0.199) 0.191 (− 0.182, 0.639) 0.289
MD − 0.102 (− 0.320, 0.116) − 0.077 (− 0.335, 0.196) − 0.115 (− 0.519, 0.255) 0.505
CC Splenium FA 0.035 (− 0.209, 0.280) − 0.135 (− 0.433, 0.182) 0.302 (− 0.071, 0.743) 0.380
MD 0.238 (0.005, 0.471)* 0.140 (− 0.173, 0.430) 0.355 (− 0.007, 0.771) 0.169
Fornix FA − 0.016 (− 0.259, 0.227) 0.082 (− 0.242, 0.405) − 0.157 (− 0.558, 0.228) 0.383
MD 0.030 (− 0.203, 0.263) 0.039 (− 0.296, 0.377) 0.022 (− 0.330, 0.372) 0.802
Left IFO FA 0.169 (− 0.035, 0.373) 0.190 (− 0.102, 0.460) 0.154 (− 0.153, 0.494) 0.691
MD − 0.040 (− 0.239, 0.159) 0.010 (− 0.253, 0.271) − 0.151 (− 0.487, 0.161) 0.872
Right IFO FA − 0.080 (− 0.302, 0.142) −0.042 (− 0.274, 0.208) −0.095 (− 0.539, 0.303) 0.316
MD 0.182 (−0.037, 0.401) 0.280 (−0.011, 0.566) − 0.020 (− 0.369, 0.328) 0.769
Left ILF FA 0.008 (−0.200, 0.217) 0.084 (− 0.198, 0.358) −0.100 (− 0.445, 0.238) 0.467
MD 0.072 (−0.116, 0.261) 0.133 (−0.157, 0.402) − 0.026 (− 0.294, 0.245) 0.777
Right ILF FA −0.146 (− 0.378, 0.086) −0.106 (− 0.435, 0.222) −0.199 (− 0.565, 0.153) 0.687
MD 0.249 (0.046, 0.452)* 0.352 (0.067, 0.673)* 0.011 (−0.259, 0.277) 0.566
Left Pyramidal FA 0.017 (−0.210, 0.244) −0.038 (− 0.279, 0.217) 0.112 (− 0.292, 0.563) 0.926
MD 0.066 (−0.145, 0.278) 0.045 (− 0.263, 0.355) 0.069 (− 0.242, 0.364) 0.487
Right Pyramidal FA 0.006 (−0.216, 0.227) −0.104 (− 0.431, 0.216) 0.217 (− 0.120, 0.518) 0.340
MD 0.180 (−0.043, 0.403) 0.270 (− 0.040, 0.640) −0.040 (− 0.326, 0.259) 0.368
Left SLF FA 0.002 (− 0.221, 0.226) −0.025 (− 0.301, 0.258) 0.033 (− 0.349, 0.428) 0.860
MD −0.005 (− 0.210, 0.199) 0.032 (− 0.241, 0.299) − 0.085 (− 0.421, 0.254) 0.948
Right SLF FA − 0.007 (− 0.223, 0.209) −0.009 (− 0.285, 0.268) 0.043 (− 0.310, 0.406) 0.435
MD 0.080 (−0.118, 0.279) 0.095 (− 0.159, 0.332) − 0.005 (− 0.332, 0.322) 0.276
Left Uncinate FA 0.091 (− 0.135, 0.316) 0.029 (− 0.274, 0.328) 0.237 (− 0.082, 0.603) 0.671
MD −0.025 (− 0.239, 0.190) 0.208 (− 0.066, 0.490) − 0.404 (− 0.726, − 0.080)* 0.010
Right Uncinate FA − 0.030 (− 0.253, 0.193) − 0.148 (− 0.404, 0.144) 0.144 (− 0.219, 0.551) 0.685
MD −0.002 (− 0.231, 0.227) −0.505 (− 0.774,-0.246) −0.096 (− 0.532, 0.308) 0.229
  1. Note: *p <.05
  2. FA fractional anisotropy, MD mean diffusivity, CC corpus callosum, IFO inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, SLF superior longitudinal fasciculus
  3. Models including all children were adjusted for maternal urinary creatinine, child sex and child age at scan. Models stratified by sex were adjusted for maternal urinary creatinine and child age at scan
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