Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children

Grohs, Melody N.; Reynolds, Jess E.; Liu, Jiaying; Martin, Jonathan W.; Pollock, Tyler; Lebel, Catherine; Dewey, Deborah

doi:10.1186/s12940-019-0528-9

Environmental Health

Table 4 Associations between prenatal maternal urinary BPA and white matter tract parameters by child age

From: Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children

Tract	DTI Parameter	All Children B (95% CI) (N = 98)	Younger (< 3.52 yrs) B (95% CI) (N = 49)	Older (> 3.52 yrs) B (95% CI) (N = 49)	Tract x Age p-value
Left Cingulum	FA	0.007 (− 0.213, 0.226)	− 0.183 (− 0.506, 0.156)	0.058 (− 0.262, 0.373)	0.716
Left Cingulum	MD	0.056 (− 0.156, 0.269)	−0.055 (− 0.414, 0.310)	0.151 (− 0.150, 0.444)	0.260
Right Cingulum	FA	0.133 (−0.089, 0.354)	0.013 (− 0.312, 0.333)	0.155 (− 0.162, 0.488)	0.775
Right Cingulum	MD	0.090 (−0.116, 0.295)	−0.096 (− 0.441, 0.265)	0.258 (− 0.031, 0.551)	0.115
CC Body	FA	0.034 (−0.195, 0.262)	0.013 (− 0.392, 0.418)	0.060 (− 0.234, 0.334)	0.596
CC Body	MD	0.041 (− 0.172, 0.254)	−0.024 (− 0.382, 0.336)	0.094 (− 0.207, 0.388)	0.278
CC Genu	FA	0.051 (−0.174, 0.276)	0.198 (− 0.176, 0.558)	−0.057 (− 0.385, 0.273)	0.682
CC Genu	MD	−0.102 (− 0.320, 0.116)	−0.295 (− 0.659, 0.090)	0.039 (− 0.274, 0.345)	0.330
CC Splenium	FA	0.035 (−0.209, 0.280)	0.151 (− 0.231, 0.531)	0.024 (− 0.311, 0.360)	0.972
CC Splenium	MD	0.238 (0.005, 0.471)*	0.045 (−0.290, 0.372)	0.293 (−0.026, 0.670)	0.648
Fornix	FA	−0.016 (− 0.259, 0.227)	−0.348 (− 0.726, 0.030)	0.335 (0.010, 0.661)*	0.040
Fornix	MD	0.030 (−0.203, 0.263)	−0.057 (− 0.403, 0.297)	0.061 (− 0.291, 0.422)	0.438
Left IFO	FA	0.169 (−0.035, 0.373)	0.090 (− 0.224, 0.356)	0.193 (− 0.162, 0.607)	0.575
Left IFO	MD	−0.040 (− 0.239, 0.159)	−0.105 (− 0.446, 0.252)	−0.058 (− 0.355, 0.244)	0.852
Right IFO	FA	−0.080 (− 0.302, 0.142)	−0.299 (− 0.515, 0.065)	0.046 (− 0.347, 0.456)	0.928
Right IFO	MD	0.182 (−0.037, 0.401)	0.215 (− 0.154, 0.581)	0.103 (− 0.212, 0.402)	0.878
Left ILF	FA	0.008 (−0.200, 0.217)	0.207 (−0.162, 0.564)	− 0.115 (− 0.415, 0.199)	0.628
Left ILF	MD	0.072 (−0.116, 0.261)	0.076 (− 0.261, 0.396)	0.103 (− 0.200, 0.413)	0.314
Right ILF	FA	−0.146 (− 0.378, 0.086)	−0.268 (− 0.675, 0.122)	0.019 (− 0.285, 0.318)	0.327
Right ILF	MD	0.249 (0.046, 0.452)*	0.284 (−0.089, 0.645)	0.240 (−0.050, 0.480)	0.969
Left Pyramidal	FA	0.017 (−0.210, 0.244)	−0.074 (− 0.384, 0.261)	0.078 (− 0.298, 0.477)	0.567
Left Pyramidal	MD	0.066 (−0.145, 0.278)	− 0.095 (− 0.422, 0.248)	0.152 (− 0.167, 0.484)	0.289
Right Pyramidal	FA	0.006 (− 0.216, 0.227)	−0.080 (− 0.392, 0.255)	0.095 (− 0.257, 0.469)	0.496
Right Pyramidal	MD	0.180 (−0.043, 0.403)	0.109 (− 0.240, 0.429)	0.223 (− 0.114, 0.608)	0.221
Left SLF	FA	0.002 (−0.221, 0.226)	−0.248 (− 0.569, 0.126)	0.128 (− 0.212, 0.485)	0.746
Left SLF	MD	−0.005 (− 0.210, 0.199)	−0.058 (− 0.405, 0.296)	0.028 (− 0.274, 0.330)	0.223
Right SLF	FA	−0.007 (− 0.223, 0.209)	−0.218 (− 0.535, 0.152)	0.131 (− 0.185, 0.459)	0.642
Right SLF	MD	0.080 (−0.118, 0.279)	0.041 (− 0.291, 0.362)	0.093 (− 0.206, 0.394)	0.242
Left Uncinate	FA	0.091 (−0.135, 0.316)	0.045 (−0.290, 0.363)	0.126 (− 0.230, 0.517)	0.260
Left Uncinate	MD	−0.025 (− 0.239, 0.190)	−0.166 (− 0.498, 0.205)	0.054 (− 0.282, 0.390)	0.304
Right Uncinate	FA	−0.030 (− 0.253, 0.193)	0.004 (− 0.354, 0.362)	−0.004 (− 0.341, 0.332)	0.451
Right Uncinate	MD	−0.002 (− 0.231, 0.227)	0.064 (− 0.304, − 0.422)	−0.113 (− 0.449, 0.221)	0.320

Note: *p < .05
FA fractional anisotropy, MD mean diffusivity, CC corpus callosum, IFO inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, SLF superior longitudinal fasciculus
Models including all children were adjusted for maternal urinary creatinine, child sex and child age at scan. Models stratified by median age were adjusted for maternal urinary creatinine and child sex

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