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Table 4 Associations between prenatal maternal urinary BPA and white matter tract parameters by child age

From: Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children

Tract DTI Parameter All Children
B (95% CI)
(N = 98)
Younger (< 3.52 yrs)
B (95% CI)
(N = 49)
Older (> 3.52 yrs)
B (95% CI)
(N = 49)
Tract x Age
p-value
Left Cingulum FA 0.007 (− 0.213, 0.226) − 0.183 (− 0.506, 0.156) 0.058 (− 0.262, 0.373) 0.716
MD 0.056 (− 0.156, 0.269) −0.055 (− 0.414, 0.310) 0.151 (− 0.150, 0.444) 0.260
Right Cingulum FA 0.133 (−0.089, 0.354) 0.013 (− 0.312, 0.333) 0.155 (− 0.162, 0.488) 0.775
MD 0.090 (−0.116, 0.295) −0.096 (− 0.441, 0.265) 0.258 (− 0.031, 0.551) 0.115
CC Body FA 0.034 (−0.195, 0.262) 0.013 (− 0.392, 0.418) 0.060 (− 0.234, 0.334) 0.596
MD 0.041 (− 0.172, 0.254) −0.024 (− 0.382, 0.336) 0.094 (− 0.207, 0.388) 0.278
CC Genu FA 0.051 (−0.174, 0.276) 0.198 (− 0.176, 0.558) −0.057 (− 0.385, 0.273) 0.682
MD −0.102 (− 0.320, 0.116) −0.295 (− 0.659, 0.090) 0.039 (− 0.274, 0.345) 0.330
CC Splenium FA 0.035 (−0.209, 0.280) 0.151 (− 0.231, 0.531) 0.024 (− 0.311, 0.360) 0.972
MD 0.238 (0.005, 0.471)* 0.045 (−0.290, 0.372) 0.293 (−0.026, 0.670) 0.648
Fornix FA −0.016 (− 0.259, 0.227) −0.348 (− 0.726, 0.030) 0.335 (0.010, 0.661)* 0.040
MD 0.030 (−0.203, 0.263) −0.057 (− 0.403, 0.297) 0.061 (− 0.291, 0.422) 0.438
Left IFO FA 0.169 (−0.035, 0.373) 0.090 (− 0.224, 0.356) 0.193 (− 0.162, 0.607) 0.575
MD −0.040 (− 0.239, 0.159) −0.105 (− 0.446, 0.252) −0.058 (− 0.355, 0.244) 0.852
Right IFO FA −0.080 (− 0.302, 0.142) −0.299 (− 0.515, 0.065) 0.046 (− 0.347, 0.456) 0.928
MD 0.182 (−0.037, 0.401) 0.215 (− 0.154, 0.581) 0.103 (− 0.212, 0.402) 0.878
Left ILF FA 0.008 (−0.200, 0.217) 0.207 (−0.162, 0.564) − 0.115 (− 0.415, 0.199) 0.628
MD 0.072 (−0.116, 0.261) 0.076 (− 0.261, 0.396) 0.103 (− 0.200, 0.413) 0.314
Right ILF FA −0.146 (− 0.378, 0.086) −0.268 (− 0.675, 0.122) 0.019 (− 0.285, 0.318) 0.327
MD 0.249 (0.046, 0.452)* 0.284 (−0.089, 0.645) 0.240 (−0.050, 0.480) 0.969
Left Pyramidal FA 0.017 (−0.210, 0.244) −0.074 (− 0.384, 0.261) 0.078 (− 0.298, 0.477) 0.567
MD 0.066 (−0.145, 0.278) − 0.095 (− 0.422, 0.248) 0.152 (− 0.167, 0.484) 0.289
Right Pyramidal FA 0.006 (− 0.216, 0.227) −0.080 (− 0.392, 0.255) 0.095 (− 0.257, 0.469) 0.496
MD 0.180 (−0.043, 0.403) 0.109 (− 0.240, 0.429) 0.223 (− 0.114, 0.608) 0.221
Left SLF FA 0.002 (−0.221, 0.226) −0.248 (− 0.569, 0.126) 0.128 (− 0.212, 0.485) 0.746
MD −0.005 (− 0.210, 0.199) −0.058 (− 0.405, 0.296) 0.028 (− 0.274, 0.330) 0.223
Right SLF FA −0.007 (− 0.223, 0.209) −0.218 (− 0.535, 0.152) 0.131 (− 0.185, 0.459) 0.642
MD 0.080 (−0.118, 0.279) 0.041 (− 0.291, 0.362) 0.093 (− 0.206, 0.394) 0.242
Left Uncinate FA 0.091 (−0.135, 0.316) 0.045 (−0.290, 0.363) 0.126 (− 0.230, 0.517) 0.260
MD −0.025 (− 0.239, 0.190) −0.166 (− 0.498, 0.205) 0.054 (− 0.282, 0.390) 0.304
Right Uncinate FA −0.030 (− 0.253, 0.193) 0.004 (− 0.354, 0.362) −0.004 (− 0.341, 0.332) 0.451
MD −0.002 (− 0.231, 0.227) 0.064 (− 0.304, − 0.422) −0.113 (− 0.449, 0.221) 0.320
  1. Note: *p < .05
  2. FA fractional anisotropy, MD mean diffusivity, CC corpus callosum, IFO inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, SLF superior longitudinal fasciculus
  3. Models including all children were adjusted for maternal urinary creatinine, child sex and child age at scan. Models stratified by median age were adjusted for maternal urinary creatinine and child sex