Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange

Kelsey, Karl T.; Rytel, Matthew; Dere, Edward; Butler, Rondi; Eliot, Melissa; Huse, Susan M.; Houseman, E. Andres; Koestler, Devin C.; Boekelheide, Kim

doi:10.1186/s12940-019-0533-z

Environmental Health

Table 2 Top 50 EWAS loci ranked by the change in beta value comparing highest exposed with control

From: Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange

Gene	CpG	CHR	Distance to TSS	Change in beta value	P-value	Mean beta in high expos	Mean beta in low expos
UMODL1	cg08880261	21	66	− 0.6	5.00E-04	0.24	0.53
NLRC5	cg03146649	16	175	−0.36	0.0013	0.6	0.8
CCL3L3,CCL3L1	cg03071134	17	2255	0.35	0.001	0.87	0.65
	cg16316180	10	3767	−0.31	4.00E-04	0.43	0.63
SERPINA6	cg11054397	14	2039	0.3	1.00E-04	0.98	0.8
	cg25345625	10	3889	−0.28	8.00E-04	0.34	0.51
	cg20710519	5	267	−0.26	0.0011	0.32	0.61
NRBP2	cg00061150	8	380	−0.26	0.0013	0.61	0.77
TRPV2	cg04702538	17	117	0.25	2.00E-04	0.93	0.85
NRBP2	cg24023418	8	534	− 0.24	6.00E-04	0.68	0.84
KDM2B	cg04682193	12	354	−0.24	0.0012	0.76	0.9
SPAM1	cg04471202	7	906	0.23	6.00E-04	0.31	0.17
ERICH1	cg02209998	8	384	0.22	4.00E-04	0.8	0.7
	cg04038019	20	501	−0.21	5.00E-04	0.71	0.84
PTPRN2	cg23887345	7	14,040	−0.21	8.00E-04	0.26	0.46
C9orf5	cg14364129	9	940	−0.2	9.00E-04	0.7	0.78
TEAD3	cg14909614	6	694	−0.2	0.0012	0.19	0.31
NRBP2	cg12515402	8	653	−0.19	4.00E-04	0.64	0.75
ARHGEF10	cg06807837	8	412	−0.19	1.00E-04	0.35	0.54
	cg14635160	9	3896	0.19	0.0014	0.25	0.12
	cg19356629	10	3037	−0.19	7.00E-04	0.74	0.86
CCL3	cg22518733	17	1973	−0.19	8.00E-04	0.57	0.66
ARHGEF10	cg07694735	8	348	−0.18	9.00E-04	0.32	0.5
	cg23154021	12	174	−0.18	0.0011	0.41	0.61
TEAD3	cg22424903	6	1059	−0.18	6.00E-04	0.11	0.22
	cg08576350	20	608	−0.17	4.00E-04	0.76	0.89
TEAD3	cg01487910	6	563	−0.17	6.00E-04	0.14	0.24
	cg14181345	9	1634	−0.17	3.46E-05	0.65	0.72
CADPS2	cg23390958	7	315	0.16	3.00E-04	0.99	0.92
AJAP1	cg21159274	1	808	−0.15	0.0011	0.42	0.52
ACCN1	cg15744026	17	1045	0.14	0.001	0.53	0.51
TEAD3	cg01546820	6	263	−0.13	5.00E-04	0.08	0.16
WDR27	cg00392003	6	2873	−0.12	4.00E-04	0.6	0.68
EPAS1	cg09119656	2	533	0.12	2.00E-04	0.99	0.94
	cg27511894	1	544	0.12	0.0014	0.82	0.76
CLEC4E	cg12762799	12	410	−0.12	6.00E-04	0.39	0.45
	cg05240760	2	75,792	0.11	7.00E-04	0.78	0.78
ATP10A	cg07986058	15	26	−0.11	0.0011	0.34	0.41
EPB41L3	cg01673082	18	2874	−0.1	4.70E-05	0.14	0.21
	cg06654337	6	12,717	−0.6	5.00E-04	0.15	0.16
WTIP	cg05620261	19	804	−0.36	0.001	0.02	0.12
FAM120A	cg15886017	9	322	0.35	5.77E-05	0.77	0.83
DHRS7B	cg06582708	17	945	−0.31	4.00E-04	0.33	0.31
C4orf42	cg21793579	4	1100	0.3	1.00E-04	0.28	0.28
RNASE1	cg05958352	14	789	−0.28	8.00E-04	0.69	0.76
NTNG1	cg14787581	1	1367	−0.26	0.0011	0.79	0.76
	cg12951997	12	1369	−0.26	0.0013	0.88	0.91
TUBB8	cg09677976	10	1317	0.25	2.00E-04	0.03	0.05
	cg07320695	4	5635	−0.24	6.00E-04	0.26	0.22
	cg19648967	14	2607	−0.24	0.0012	0.72	0.76

Back to article page

ISSN: 1476-069X

Contact us

General enquiries: journalsubmissions@springernature.com