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Table 2 Top 50 EWAS loci ranked by the change in beta value comparing highest exposed with control

From: Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange

Gene CpG CHR Distance to TSS Change in beta value P-value Mean beta in high expos Mean beta in low expos
UMODL1 cg08880261 21 66 − 0.6 5.00E-04 0.24 0.53
NLRC5 cg03146649 16 175 −0.36 0.0013 0.6 0.8
CCL3L3,CCL3L1 cg03071134 17 2255 0.35 0.001 0.87 0.65
  cg16316180 10 3767 −0.31 4.00E-04 0.43 0.63
SERPINA6 cg11054397 14 2039 0.3 1.00E-04 0.98 0.8
  cg25345625 10 3889 −0.28 8.00E-04 0.34 0.51
  cg20710519 5 267 −0.26 0.0011 0.32 0.61
NRBP2 cg00061150 8 380 −0.26 0.0013 0.61 0.77
TRPV2 cg04702538 17 117 0.25 2.00E-04 0.93 0.85
NRBP2 cg24023418 8 534 − 0.24 6.00E-04 0.68 0.84
KDM2B cg04682193 12 354 −0.24 0.0012 0.76 0.9
SPAM1 cg04471202 7 906 0.23 6.00E-04 0.31 0.17
ERICH1 cg02209998 8 384 0.22 4.00E-04 0.8 0.7
  cg04038019 20 501 −0.21 5.00E-04 0.71 0.84
PTPRN2 cg23887345 7 14,040 −0.21 8.00E-04 0.26 0.46
C9orf5 cg14364129 9 940 −0.2 9.00E-04 0.7 0.78
TEAD3 cg14909614 6 694 −0.2 0.0012 0.19 0.31
NRBP2 cg12515402 8 653 −0.19 4.00E-04 0.64 0.75
ARHGEF10 cg06807837 8 412 −0.19 1.00E-04 0.35 0.54
  cg14635160 9 3896 0.19 0.0014 0.25 0.12
  cg19356629 10 3037 −0.19 7.00E-04 0.74 0.86
CCL3 cg22518733 17 1973 −0.19 8.00E-04 0.57 0.66
ARHGEF10 cg07694735 8 348 −0.18 9.00E-04 0.32 0.5
  cg23154021 12 174 −0.18 0.0011 0.41 0.61
TEAD3 cg22424903 6 1059 −0.18 6.00E-04 0.11 0.22
  cg08576350 20 608 −0.17 4.00E-04 0.76 0.89
TEAD3 cg01487910 6 563 −0.17 6.00E-04 0.14 0.24
  cg14181345 9 1634 −0.17 3.46E-05 0.65 0.72
CADPS2 cg23390958 7 315 0.16 3.00E-04 0.99 0.92
AJAP1 cg21159274 1 808 −0.15 0.0011 0.42 0.52
ACCN1 cg15744026 17 1045 0.14 0.001 0.53 0.51
TEAD3 cg01546820 6 263 −0.13 5.00E-04 0.08 0.16
WDR27 cg00392003 6 2873 −0.12 4.00E-04 0.6 0.68
EPAS1 cg09119656 2 533 0.12 2.00E-04 0.99 0.94
  cg27511894 1 544 0.12 0.0014 0.82 0.76
CLEC4E cg12762799 12 410 −0.12 6.00E-04 0.39 0.45
  cg05240760 2 75,792 0.11 7.00E-04 0.78 0.78
ATP10A cg07986058 15 26 −0.11 0.0011 0.34 0.41
EPB41L3 cg01673082 18 2874 −0.1 4.70E-05 0.14 0.21
  cg06654337 6 12,717 −0.6 5.00E-04 0.15 0.16
WTIP cg05620261 19 804 −0.36 0.001 0.02 0.12
FAM120A cg15886017 9 322 0.35 5.77E-05 0.77 0.83
DHRS7B cg06582708 17 945 −0.31 4.00E-04 0.33 0.31
C4orf42 cg21793579 4 1100 0.3 1.00E-04 0.28 0.28
RNASE1 cg05958352 14 789 −0.28 8.00E-04 0.69 0.76
NTNG1 cg14787581 1 1367 −0.26 0.0011 0.79 0.76
  cg12951997 12 1369 −0.26 0.0013 0.88 0.91
TUBB8 cg09677976 10 1317 0.25 2.00E-04 0.03 0.05
  cg07320695 4 5635 −0.24 6.00E-04 0.26 0.22
  cg19648967 14 2607 −0.24 0.0012 0.72 0.76