Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange

Kelsey, Karl T.; Rytel, Matthew; Dere, Edward; Butler, Rondi; Eliot, Melissa; Huse, Susan M.; Houseman, E. Andres; Koestler, Devin C.; Boekelheide, Kim

doi:10.1186/s12940-019-0533-z

Environmental Health

Table 3 Mean DNA methylation in sperm by exposure group in 37 candidate CpG loci

From: Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange

Gene	CpG	Russian Low Exposure Group	Russian High Exposure Group	Ranch Hand Low Exposure	Ranch Hand High Exposure	P-value	FDR adjusted p-value
SAMD11	cg06624358	0.58	0.92	0.66	0.61	0.72	0.81
SAMD11	cg14156792	0.51	0.97	0.60	0.55	0.77	0.81
SAMD11	cg01727431	0.59	1	0.59	0.53	0.67	0.80
SAMD11	cg02439789	0.46	0.83	0.58	0.49	0.51	0.80
PGBD5	cg11570508	0.92	0.72	0.97	0.92	0.047	0.35
PGBD5	cg11226042	0.97	0.58	0.93	0.87	0.039	0.35
PGBD5	cg22875527	0.95	0.61	0.95	0.89	0.027	0.5
CCNY	cg05701548	0.14	0.38	0.57	0.55	0.77	0.81
RBP3	cg07070043	0.76	0.34	0.66	0.56	0.035	0.35
	cg26066724	0.88	0.32	0.75	0.65	0.34	0.63
	cg07458849	0.91	0.80	0.88	0.87	0.87	0.87
SLC5A10	cg04585390	0.60	0.35	0.58	0.52	0.34	0.63
MBP	cg00706570	0.76	0.40	0.72	0.47	0.005	0.185
	cg06167221	0.69	0.80	0.79	0.69	0.12	0.40
	cg00593773	0.61	0.82	0.85	0.77	0.10	0.40
KCNN1	cg21491340	0.17	0.07	0.38	0.30	0.096	0.40
KCNN1	cg21491340	0.14	0.05	0.38	0.30	0.096	0.40
FBLN7	cg11229230	0.83	0.96	0.98	0.97	0.20	0.60
DGKD	cg24933152	1	0.92	0.9778	0.9818	0.060	0.37
FAM83C	cg12170299	0.78	0.72	0.67	0.63	0.27	0.63
FAM83C	cg11133013	0.858	0.63	0.73	0.64	0.21	0.60
C21orf29	cg12061357	0.61	0.25	0.60	0.51	0.12	0.40
	cg26311420	0.56	0.15	0.40	0.45	0.66	0.80
	cg26311420	0.5	0.13	0.40	0.45	0.66	0.80
RBM33	cg14353208	0.82	0.99	0.98	0.97	0.48	0.80
RBM33	cg07262012	0.80	0.97	0.96	0.96	0.53	0.80
	cg14720951	0.28	0.14	0.13	0.17	0.34	0.63
	cg06182811	0.75	0.73	0.69	0.74	0.31	0.63
	cg06182811	0.85	0.74	0.69	0.74	0.31	0.63
	cg19673480	0.83	0.64	0.77	0.79	0.64	0.80
	cg19673480	0.82	0.59	0.77	0.79	0.64	0.80
	cg23541013	0.71	0.44	0.72	0.77	0.33	0.63
	cg01695620	0.74	0.61	0.83	0.87	0.43	0.76
	cg15690180	0.55	0.19	0.46	0.49	0.77	0.81
FLJ43860	cg12732638	0.65	0.84	0.84	0.85	0.79	0.81
PLEC1	cg04247530	0.86	0.94	0.84	0.82	0.55	0.80
TBC1D2	cg14049807	0.06	0.26	0.43	0.39	0.62	0.80

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ISSN: 1476-069X

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