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Table 4 CpG regions (by P-Value) identified as altered in DMRcate analysis of Agent Orange exposed compared with control

From: Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange

CHR Start End Width #
CpGs
P-value Stouffer Adjusted p-value Max beta-fold change Mean beta-fold change Overlapping
Genes
11 2,016,513 2,020,560 4048 50 1.83E-29 1 −0.13 − 0.04 H19
19 35,530,254 35,532,097 1844 9 5.77E-15 0.93 −0.21 −0.15 HPN
1 32,041,052 32,042,921 1870 12 8.02E-15 0.99 − 0.15 − 0.08 TINAGL1
20 62,205,530 62,205,981 452 9 6.21E-14 0.93 −0.12 − 0.09 HELZ2
20 57,581,478 57,583,709 2232 27 3.21E-13 1 −0.05 − 0.01 CTSZ
17 75,315,081 75,317,185 2105 15 2.27E-12 0.99 −0.15 −0.07 SEPT9
11 2,441,045 2,442,304 1260 7 4.08E-12 0.91 −0.16 −0.14 TRPM5
22 37,640,250 37,641,506 1257 7 5.82E-12 0.92 −0.11 −0.09 RAC2
19 6,772,370 6,773,074 705 4 2.23E-11 0.84 −0.12 −0.08 VAV1
5 2,007,375 2,008,713 1339 8 1.16E-10 0.92 −0.15 −0.13 NA
16 725,416 730,187 4772 17 1.66E-10 1 −0.07 −0.01 STUB1, RHBDL1, LA16c
16 4,729,905 4,733,181 3277 14 1.73E-10 1 −0.2 −0.05 MGRN1
18 74,691,097 74,692,265 1169 9 3.00E-10 0.93 −0.2 −0.17 RP11
1 6,129,242 6,134,427 5186 10 5.30E-10 0.99 0.03 0 NA
14 74,823,368 74,824,804 1437 8 7.83E-10 0.92 −0.11 −0.07 NA
20 60,540,388 60,541,082 695 5 9.37E-10 0.87 −0.17 −0.15 NA
6 169,653,612 169,655,497 1886 12 1.24E-09 0.98 −0.13 −0.06 THBS2
1 6,085,799 6,086,652 854 9 1.59E-09 0.95 −0.2 −0.16 KCNAB2
2 495,912 497,296 1385 7 9.03E-09 0.96 −0.17 −0.1 NA
12 133,463,607 133,465,592 1986 31 1.96E-08 1 0.08 0.01 CHFR, RP11
11 2,554,198 2,555,576 1379 11 2.30E-08 0.98 −0.14 −0.05 NA
9 124,497,763 124,499,870 2108 6 2.73E-08 0.94 −0.02 −0.01 NA
17 68,171,276 68,171,750 475 3 5.25E-08 0.78 0.01 0.01 NA
5 6,775,909 6,775,922 14 2 2.52E-07 0.76 −0.21 −0.2 NA
1 203,840,145 203,840,808 664 2 2.71E-07 0.76 0.02 0.01 NA
7 100,727,888 100,729,412 1525 10 5.27E-07 0.96 −0.1 −0.07 TRIM56
11 68,778,570 68,782,202 3633 19 5.73E-07 1 −0.08 −0.03 MRGPRF, RP11
1 203,320,190 203,320,541 352 5 6.54E-07 0.87 −0.15 −0.12 FMOD
7 73,441,057 73,443,113 2057 8 7.83E-07 0.95 −0.12 −0.08 ELN
11 3,186,095 3,188,016 1922 28 8.03E-07 1 −0.09 −0.04 OSBPL5
17 790,628 791,324 697 5 9.74E-07 0.99 0.02 0.01 NA