Table 4 CpG regions (by P-Value) identified as altered in DMRcate analysis of Agent Orange exposed compared with control
CHR | Start | End | Width | # CpGs | P-value | Stouffer Adjusted p-value | Max beta-fold change | Mean beta-fold change | Overlapping Genes |
|---|---|---|---|---|---|---|---|---|---|
11 | 2,016,513 | 2,020,560 | 4048 | 50 | 1.83E-29 | 1 | −0.13 | − 0.04 | H19 |
19 | 35,530,254 | 35,532,097 | 1844 | 9 | 5.77E-15 | 0.93 | −0.21 | −0.15 | HPN |
1 | 32,041,052 | 32,042,921 | 1870 | 12 | 8.02E-15 | 0.99 | − 0.15 | − 0.08 | TINAGL1 |
20 | 62,205,530 | 62,205,981 | 452 | 9 | 6.21E-14 | 0.93 | −0.12 | − 0.09 | HELZ2 |
20 | 57,581,478 | 57,583,709 | 2232 | 27 | 3.21E-13 | 1 | −0.05 | − 0.01 | CTSZ |
17 | 75,315,081 | 75,317,185 | 2105 | 15 | 2.27E-12 | 0.99 | −0.15 | −0.07 | SEPT9 |
11 | 2,441,045 | 2,442,304 | 1260 | 7 | 4.08E-12 | 0.91 | −0.16 | −0.14 | TRPM5 |
22 | 37,640,250 | 37,641,506 | 1257 | 7 | 5.82E-12 | 0.92 | −0.11 | −0.09 | RAC2 |
19 | 6,772,370 | 6,773,074 | 705 | 4 | 2.23E-11 | 0.84 | −0.12 | −0.08 | VAV1 |
5 | 2,007,375 | 2,008,713 | 1339 | 8 | 1.16E-10 | 0.92 | −0.15 | −0.13 | NA |
16 | 725,416 | 730,187 | 4772 | 17 | 1.66E-10 | 1 | −0.07 | −0.01 | STUB1, RHBDL1, LA16c |
16 | 4,729,905 | 4,733,181 | 3277 | 14 | 1.73E-10 | 1 | −0.2 | −0.05 | MGRN1 |
18 | 74,691,097 | 74,692,265 | 1169 | 9 | 3.00E-10 | 0.93 | −0.2 | −0.17 | RP11 |
1 | 6,129,242 | 6,134,427 | 5186 | 10 | 5.30E-10 | 0.99 | 0.03 | 0 | NA |
14 | 74,823,368 | 74,824,804 | 1437 | 8 | 7.83E-10 | 0.92 | −0.11 | −0.07 | NA |
20 | 60,540,388 | 60,541,082 | 695 | 5 | 9.37E-10 | 0.87 | −0.17 | −0.15 | NA |
6 | 169,653,612 | 169,655,497 | 1886 | 12 | 1.24E-09 | 0.98 | −0.13 | −0.06 | THBS2 |
1 | 6,085,799 | 6,086,652 | 854 | 9 | 1.59E-09 | 0.95 | −0.2 | −0.16 | KCNAB2 |
2 | 495,912 | 497,296 | 1385 | 7 | 9.03E-09 | 0.96 | −0.17 | −0.1 | NA |
12 | 133,463,607 | 133,465,592 | 1986 | 31 | 1.96E-08 | 1 | 0.08 | 0.01 | CHFR, RP11 |
11 | 2,554,198 | 2,555,576 | 1379 | 11 | 2.30E-08 | 0.98 | −0.14 | −0.05 | NA |
9 | 124,497,763 | 124,499,870 | 2108 | 6 | 2.73E-08 | 0.94 | −0.02 | −0.01 | NA |
17 | 68,171,276 | 68,171,750 | 475 | 3 | 5.25E-08 | 0.78 | 0.01 | 0.01 | NA |
5 | 6,775,909 | 6,775,922 | 14 | 2 | 2.52E-07 | 0.76 | −0.21 | −0.2 | NA |
1 | 203,840,145 | 203,840,808 | 664 | 2 | 2.71E-07 | 0.76 | 0.02 | 0.01 | NA |
7 | 100,727,888 | 100,729,412 | 1525 | 10 | 5.27E-07 | 0.96 | −0.1 | −0.07 | TRIM56 |
11 | 68,778,570 | 68,782,202 | 3633 | 19 | 5.73E-07 | 1 | −0.08 | −0.03 | MRGPRF, RP11 |
1 | 203,320,190 | 203,320,541 | 352 | 5 | 6.54E-07 | 0.87 | −0.15 | −0.12 | FMOD |
7 | 73,441,057 | 73,443,113 | 2057 | 8 | 7.83E-07 | 0.95 | −0.12 | −0.08 | ELN |
11 | 3,186,095 | 3,188,016 | 1922 | 28 | 8.03E-07 | 1 | −0.09 | −0.04 | OSBPL5 |
17 | 790,628 | 791,324 | 697 | 5 | 9.74E-07 | 0.99 | 0.02 | 0.01 | NA |