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Table 2 Top gene sets associated with arsenic exposure

From: Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study

Gene setNES
A. Female
 Upregulated
  KEGG OXIDATIVE PHOSPHORYLATION3.86
  REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS3.76
  REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION3.75
  REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION3.71
  REACTOME MEMBRANE TRAFFICKING3.70
 Downregulated
  NABA CORE MATRISOME−4.59
  REACTOME PEPTIDE CHAIN ELONGATION−4.57
  KEGG RIBOSOME−4.40
  REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION−4.12
  REACTOME SIGNALING BY GPCR−3.87
B. Male
 Upregulated
  REACTOME UNFOLDED PROTEIN RESPONSE2.17
  REACTOME INSULIN RECEPTOR RECYCLING2.10
  REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S2.04
  REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING2.01
  REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT1.99
 Downregulated
  NABA CORE MATRISOME−2.78
  NABA ECM GLYCOPROTEINS−2.54
  PID INTEGRIN1 PATHWAY− 2.37
  KEGG VASCULAR SMOOTH MUSCLE CONTRACTION−2.36
  NABA COLLAGENS−2.36
  1. NES normalized enrichment score