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Table 3 Top 10 gene sets enriched at high arsenic exposure and reduced birth weight in female fetal placenta

From: Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study

Gene setU-As NESBirth weight NESU-As FDR valueBirth weight FDR value
NABA CORE MATRISOME−4.593.4900
KEGG OXIDATIVE PHOSPHORYLATION3.86−3.4506.51 × 10−7
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS3.76− 3.1902.87 × 10−6
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT3.69− 3.3202.17 × 10− 6
REACTOME HIV INFECTION3.25−3.611.22 × 10−50
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G3.1−3.42.93 × 10− 51.20 × 10− 6
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC3.1−3.193.13 × 10− 52.51 × 10− 6
KEGG PROTEASOME3.09−3.143.11 × 10− 53.86 × 10− 6
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI13.08−3.233.10 × 10− 52.24 × 10− 6
KEGG HUNTINGTONS DISEASE3.01−3.154.53 × 10− 53.94 × 10− 6
  1. NES normalized enrichment score