Table 3 Top 10 gene sets enriched at high arsenic exposure and reduced birth weight in female fetal placenta
Gene set | U-As NES | Birth weight NES | U-As FDR value | Birth weight FDR value |
|---|---|---|---|---|
NABA CORE MATRISOME | −4.59 | 3.49 | 0 | 0 |
KEGG OXIDATIVE PHOSPHORYLATION | 3.86 | −3.45 | 0 | 6.51 × 10−7 |
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 3.76 | − 3.19 | 0 | 2.87 × 10−6 |
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 3.69 | − 3.32 | 0 | 2.17 × 10− 6 |
REACTOME HIV INFECTION | 3.25 | −3.61 | 1.22 × 10−5 | 0 |
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | 3.1 | −3.4 | 2.93 × 10− 5 | 1.20 × 10− 6 |
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | 3.1 | −3.19 | 3.13 × 10− 5 | 2.51 × 10− 6 |
KEGG PROTEASOME | 3.09 | −3.14 | 3.11 × 10− 5 | 3.86 × 10− 6 |
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | 3.08 | −3.23 | 3.10 × 10− 5 | 2.24 × 10− 6 |
KEGG HUNTINGTONS DISEASE | 3.01 | −3.15 | 4.53 × 10− 5 | 3.94 × 10− 6 |