Use of skincare products and risk of cancer of the breast and endometrium: a prospective cohort study

Table 3 Associations between skincare product use and incidence of ER+ and ER- breast cancer

			ER + breast cancer^a				ER- breast cancer^b
User group of skincare products	n	Cancer cases	Age-adjusted HR (95% CI)	Multivariable HR (95% CI)	n	Cancer cases	Age-adjusted HR (95% CI)	Multivariable HR (95% CI)	p_{heterogeneity}^c
Non−/light users	33,309	883	1.00	1.00	35,090	157	1.00	1.00
Moderate users	22,411	585	0.98 (0.88,1.08)	0.98 (0.89,1.09)	23,475	92	0.89 (0.69,1.15)	0.91 (0.7,1.18)	0.58
Frequent/heavy users	35,784	948	0.99 (0.90,1.09)	0.99 (0.90,1.08)	37,896	159	0.95 (0.76,1.19)	0.99 (0.79,1.23)	0.99

HR hazard ratio, CI confidence interval; ER: estrogen receptor
^aMultivariable adjusted for body mass index, smoking, age at first birth and parity combined, alcohol intake, physical activity, menopausal status, maternal breast cancer history and use of menopause hormone therapy
^bMultivariable adjusted for physical activity and maternal breast cancer history
^cTest of difference in effect by breast cancer subtypes

ISSN: 1476-069X