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Table 2 Long-term chronic dietary exposure toxicity and carcinogenicity studies of glyphosate excluded from this evaluation

From: A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

Study ReferenceDuration (months)StrainDietary exposure dose levels (mg/kg/day)Animals per GroupPurity (%)Reason for exclusion
MouseRat
Reyna and Gordon (1973) [24]18SWMa M: 0, 17,50
F: 0, 17,50
50NPbEPA [25] concluded this study was likely falsified
Pavkov and Turner (1987) [26]24CD-1 M: 0, 11.7, 118, 991
F: 0, 11.7, 118, 991
5056.2EPA [6] lists this study as completely negative for tumors but provides no tumor data. No tumor data is available for this study and the purity is low.
Reyna and Gordon (1974) [27]24 SDcNot available7013.8EPA [25] concluded this study was likely falsified
Burnett et al. (1979) [28]24 SDcM: 0, 3.10.30
F: 0, 3,10,30
90NPbEPA initially reported this as a glyphosate study [29] but later removed it because it is a study of a contaminant of glyphosate [6].
Pavkov and Wyand (1987) [30]24 SDcM: 0, 4.2, 21.2, 41.8
F: 0, 5.4, 27, 55.7
80–9056.2EPA [6] lists this study as completely negative for tumors but provides very limited tumor data [31]. No tumor data is available for this study and the purity is low.
Excel (1997) [32]24 SDcM: 0, 150, 780, 1290
F: 0, 210, 1060, 1740
51NPbNo tumor data available, regulatory agencies had concerns about the quality of the study and purity of the material being studied
Takahashi (1999b) [33]24 FdM: 0, 25, 201, 1750
F: 0, 29.7, 239, 2000
50NPbThis study is only mentioned by JMPR [7] and showed body weight changes at the highest exposure which probably exceeded the MTD. No tumor data were provided although JMPR concluded there is no increased carcinogenicity.
Chruscielska (2000) [34]24 WeM: 1.9, 5.9, 17
F: 0, 2.2, 6.5, 19
85GBHfUncertainty in the material used in the study and poor reporting in the study. Note: this study is in drinking water
  1. aSwiss white mouse; bPurity not provided; cSprague-Dawley rat; dFischer F344 rats; eWistar rats; fglyphosate-based herbicide (13.8% solution, probably Perzocyd according to Greim et al. [9])