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Table 3 P-values for the Cochran-Armitage trend test and pooled logistic regression analysis for tumors with at least one significant trend test (p ≤ 0.05) or Fisher’s exact test (p ≤ 0.05) in male and female CD-1 mice

From: A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

Tumor

Individual study p-values for trenda

Common Trend

Heterogeneity Test

Males

A

B

C

D

E

  

 Kidney Adenomas

0.442 (0.138)d

0.938

0.062 (0.009)d

---b

0.019

0.006

0.268

 Kidney Carcinomas

0.063 (< 0.001)d

0.938

---b

---b

0.250

0.031

0.546

 Kidney Adenomas and Carcinomas

0.065 (0.008)d

0.981

0.062 (0.009)d

---b

0.005

< 0.001

0.106

 Malignant Lymphomas

0.754

0.087

0.016

0.007

NDc

0.093

0.007

 Hemangiosarcomas

0.505

0.004

0.062 (0.005)d

---b

NDc

0.033

0.007

 Alveolar-Bronchiolar Adenomas

0.294

0.231

0.513

0.924

NDc

0.384

0.409

 Alveolar-Bronchiolar Carcinomas

0.918

0.456

0.148

0.028

NDc

0.407

0.083

 Alveolar-Bronchiolar Adenomas and Carcinomas

0.576

0.231

0.294

0.336

NDc

0.346

0.826

Females

A

B

C

D

E

  

 Hemangiomas

0.631

---b

0.002

0.438

NDc

0.031

0.155

 Harderian Gland Adenomas

0.877

NDc

0.040

0.155

NDc

0.155

0.052

 Harderian Gland Carcinomas

---b

NDc

---b

1.000

NDc

0.500

1.00

 Harderian Gland Adenomas and Carcinomas

0.877

NDc

0.040

0.372

NDc

0.184

0.110

 Alveolar-Bronchiolar Adenomas

0.999

0.144

0.800

0.656

NDc

0.996

0.211

 Alveolar-Bronchiolar Carcinomas

0.183

0.110

0.623

0.601

NDc

0.268

0.544

 Alveolar-Bronchiolar Adenomas and Carcinomas

0.985

0.048

0.842

0.688

NDc

0.982

0.241

 Malignant Lymphomas

0.070e

0.484

0.294

0.353

0.050

0.012

0.995

  1. a – Study A is Knezevich and Hogan [11] (Additional file 2: Table S1), Study B is Atkinson et al. [12] (Additional file 2: Table S2), Study C is Sugimoto [13] (Additional file 2: Table S3), Study D is Wood [14] (Additional file 2: Table S4), Study E is Takahashi [15] (Additional file 2: Table S5); b – three dashes “---” indicates all tumor counts are zero; c – ND indicates there is no data available for this tumor in this study; d – using historical control data (see text for details) and Tarone’s test; e – Spleen composite lymphosarcomas (malignant lymphomas) are also significantly increased in female mice in this study (see Additional file 2: Table S1)