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Table 3 P-values for the Cochran-Armitage trend test and pooled logistic regression analysis for tumors with at least one significant trend test (p ≤ 0.05) or Fisher’s exact test (p ≤ 0.05) in male and female CD-1 mice

From: A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

TumorIndividual study p-values for trendaCommon TrendHeterogeneity Test
MalesABCDE  
 Kidney Adenomas0.442 (0.138)d0.9380.062 (0.009)d---b0.0190.0060.268
 Kidney Carcinomas0.063 (< 0.001)d0.938---b---b0.2500.0310.546
 Kidney Adenomas and Carcinomas0.065 (0.008)d0.9810.062 (0.009)d---b0.005< 0.0010.106
 Malignant Lymphomas0.7540.0870.0160.007NDc0.0930.007
 Hemangiosarcomas0.5050.0040.062 (0.005)d---bNDc0.0330.007
 Alveolar-Bronchiolar Adenomas0.2940.2310.5130.924NDc0.3840.409
 Alveolar-Bronchiolar Carcinomas0.9180.4560.1480.028NDc0.4070.083
 Alveolar-Bronchiolar Adenomas and Carcinomas0.5760.2310.2940.336NDc0.3460.826
FemalesABCDE  
 Hemangiomas0.631---b0.0020.438NDc0.0310.155
 Harderian Gland Adenomas0.877NDc0.0400.155NDc0.1550.052
 Harderian Gland Carcinomas---bNDc---b1.000NDc0.5001.00
 Harderian Gland Adenomas and Carcinomas0.877NDc0.0400.372NDc0.1840.110
 Alveolar-Bronchiolar Adenomas0.9990.1440.8000.656NDc0.9960.211
 Alveolar-Bronchiolar Carcinomas0.1830.1100.6230.601NDc0.2680.544
 Alveolar-Bronchiolar Adenomas and Carcinomas0.9850.0480.8420.688NDc0.9820.241
 Malignant Lymphomas0.070e0.4840.2940.3530.0500.0120.995
  1. a – Study A is Knezevich and Hogan [11] (Additional file 2: Table S1), Study B is Atkinson et al. [12] (Additional file 2: Table S2), Study C is Sugimoto [13] (Additional file 2: Table S3), Study D is Wood [14] (Additional file 2: Table S4), Study E is Takahashi [15] (Additional file 2: Table S5); b – three dashes “---” indicates all tumor counts are zero; c – ND indicates there is no data available for this tumor in this study; d – using historical control data (see text for details) and Tarone’s test; e – Spleen composite lymphosarcomas (malignant lymphomas) are also significantly increased in female mice in this study (see Additional file 2: Table S1)