A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

Portier, Christopher J.

doi:10.1186/s12940-020-00574-1

Environmental Health

Table 4 P-values for the Cochran-Armitage trend test and pooled logistic regression analysis for tumors with at least one significant trend test or Fisher’s exact test (p ≤ 0.05) in male and female Sprague-Dawley rats

From: A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

Tumor	Individual study p-values for trend^a				Common Trend	Heterogeneity Test
Males	G	H	I	J
Testicular Interstitial Cell Tumors	0.009	0.296	0.580	0.594	0.461	0.105
Pancreas Islet Cell Adenomas	0.512	0.147 (0.007)^c	0.974	0.859	0.849	0.143
Pancreas Islet Cell Carcinomas	0.251	1.000	–	0.500	0.731	0.166
Pancreas Islet Cell Adenomas or Carcinomas	0.316	0.206	0.974	0.844	0.875	0.185
Thyroid C-cell Adenomas	0.743	0.089	0.278	0.631	0.210	0.532
Thyroid C-cell Carcinomas	0.505	0.442	0.495	0.565	0.322	0.898
Thyroid C-cell Adenomas and Carcinomas	0.748	0.097	0.197	0.642	0.175	0.526
Thyroid Follicular-cell Adenomas	0.122	0.408	0.067	0.966	0.464	0.055
Thyroid Follicular-cell Carcinomas	---^b	0.255	0.443	1.000	0.448	0.137
Thyroid Follicular-cell Adenoma and Carcinoma	0.122	0.232	0.099	0.986	0.446	0.031
Hepatocellular Adenomas	0.471	0.015	0.325	0.500	0.029	0.664
Hepatocellular Carcinomas	0.062	0.637	0.760	0.642	0.803	0.269
Hepatocellular Adenomas and Carcinomas	0.173	0.050	0.480	0.690	0.144	0.428
Kidney Adenomas	0.938	0.813	1.000	0.004	0.039	0.002
Skin Keratoacanthomas	---^b	0.042	0.047	0.029	< 0.001	0.998
Skin Basal Cell Tumors	0.251	0.249	1.000	0.004	< 0.001	0.009
Females	G	H	I	J
Thyroid C-cell Adenomas	0.679	0.049	0.207	0.912	0.287	0.150
Thyroid C-cell Carcinomas	0.003 (< 0.001)^c	0.500	---^b	---^b	0.385	0.041
Thyroid C-cell Adenomas and Carcinomas	0.072 (0.037)^c	0.052	0.207	0.912	0.275	0.071
Adrenal Cortical Adenoma	0.851	0.603	---^b	0.626	0.713	0.750
Adrenal Cortical Carcinoma	0.386	0.015	0.493	---^b	0.031	0.199
Adrenal Cortical Adenoma and Carcinoma	0.801	0.090	0.493	0.626	0.195	0.520

^a – Study G is Lankas [17] (Additional file 2: Table S7), Study H is Stout and Ruecker [18] (Additional file 2: Table S8), Study I is Atkinson et al. [12] (Additional file 2: Table S9) and Study J is Enemoto [20] (Additional file 2: Table S10); ^b – three dashes “---” indicates all tumor counts are zero; ^c – using historical control data (see text for details) and Tarone’s test

Back to article page

ISSN: 1476-069X

Contact us

General enquiries: journalsubmissions@springernature.com