A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

Table 5 P-values for the Cochran-Armitage trend test and pooled logistic regression analysis for tumors with at least one significant trend test or Fisher’s exact test (p ≤ 0.05) in male and female Wistar rats

Tumor	Individual study p-values for trend^a			Common Trend	Homogeneity Test
Males	K	L	M
Hepatocellular Adenomas	0.391	0.008	0.418	0.048	0.156
Hepatocellular Carcinomas	0.418	---^b	1.000	0.492	0.242
Hepatocellular Adenomas and Carcinomas	0.286	0.008	0.610	0.029	0.194
Pituitary Adenomas	0.376	0.277	0.045	0.057	0.664
Pituitary Carcinomas	0.692	---^b	1.000	0.771	0.956
Pituitary Adenomas and Carcinomas	0.454	0.277	0.059	0.073	0.700
Skin Keratoacanthomas	---^b	0.387	0.030	0.032	0.823
Adrenal Pheochromocytomas	0.048	0.721	0.306	0.273	0.210
Females	K	L	M
Mammary Gland Adenomas	0.539	0.941	0.062	0.448	0.015
Mammary Gland Adenocarcinomas	1.000	0.271	0.042	0.071	0.008
Mammary Gland Adenomas and Adenocarcinomas	0.729	0.590	0.007	0.113	0.064
Pituitary Adenomas	0.967	0.261	0.014	0.105	0.023
Pituitary Carcinomas	1.000	–	0.750	0.748	0.491
Pituitary Adenomas and Carcinomas	0.976	0.261	0.017	0.129	0.019

^a – Study J is Suresh [21] (Additional file 2: Table S11), Study K is Brammer [22] (Additional file 2: Table S12), and Study L is Wood et al. [14] (Additional file 2: Table S13); ^b – three dashes “---” indicates all tumor counts are zero

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