Skip to main content


Fig. 1 | Environmental Health

Fig. 1

From: Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

Fig. 1

Seven DNT AOPs with multiple MIEs leading to the similar AO. Alteration of brain derived neurotrophic factor (BDNF) levels, alteration of synaptogenesis and alterations of neuronal network functions) are defined as KEs common to majority of these seven AOPs, which all lead to the adverse outcome (AO) defined as learning and memory impairment or cognitive function deficit

Back to article page