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Fig. 11 | Environmental Health

Fig. 11

From: Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

Fig. 11

Bench mark response (BMR) for BDNF protein levels. The absolute BMR of single chemicals, based on the concentrations used in the mixtures ('3-Sim' in a, '3-Diss' in b, and 'All' in c), are plotted and compared with the absolute percentage of response experimentally observed in the mixtures for BDNF (normalised to control). Although the calculated TU was > 1, a combined/potentiated mixture effect can be hypothesized, in the case when the response elicited by the mixture was at least two-folds of magnitude higher than individual chemical contributions, as indicated by the orange dashed arrow

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