Skip to main content

Advertisement

Table 4 Main effects and mixture-related LOAECs specific for each time interval and DNT endpoint

From: Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

3 days‘3-Sim’
Similar MoA
‘3-Diss’
Dissimilar MoA
‘All’
Synaptogenesis
(SYP, PSD95)
SYPt
synapses
(LOAEC/4-syn)
BPA, CPF
SYPt
synapses
(LOAEC/4-syn)
Methyl-Hg, PCB138
SYPt
(LOAEC/4-syn)
BPA, CPF, Methyl-Hg, PCB138
Neurite outgrowth and % of neurons n. branch points
neurite length
(LOAEC/4-neu)
β-III-tubulin+ neurons (LOAEC/2-neu)
CPF
n. neurites/neuron
(LOAEC/4-neu)
PCB138 (counteract)
n. neurites/neuron
(LOAEC/4-neu)
β-III-tubulin+ neurons (LOAEC-neu)
CPF
PCB138 (counteract)
BDNF levels total BDNF
(LOAEC-bdnf)
total BDNF
(LOAEC-bdnf)
total BDNF
(LOAEC/2-bdnf)
14 days‘3-Sim’
Similar MoA
‘3-Diss’
Dissimilar MoA
‘All’
Synaptogenesis
(SYP, PSD95)
SYPt
(LOAEC/2-syn)
BPA
SYPt
(LOAEC-syn)
BPA
Neurite outgrowth and % of neurons neurite length
(LOAEC/4-neu)
β-III-tubulin+ neurons (LOAEC/2-neu)
CPF, Lead
n. branch points
neurite length
β-III-tubulin+ neurons
(LOAEC/2-neu)
Methyl-Hg, PCB138,
VA (counteract)
n. branch points
neurite length
β-III-tubulin+ neurons
(LOAEC/2-neu)
CPF, Lead, Methyl-Hg, PCB138
VA (counteract)
BDNF levels total BDNF
(LOAEC/2-bdnf)
CPF, Lead
total BDNF
(LOAEC/2-bdnf)
Methyl-Hg
total BDNF
(LOAEC/2-bdnf)
CPF, Lead, Methyl-Hg