Parameters of ovarian reserve in relation to urinary concentrations of parabens

Jurewicz, Joanna; Radwan, Michał; Wielgomas, Bartosz; Karwacka, Anetta; Klimowska, Anna; Kałużny, Paweł; Radwan, Paweł; Hanke, Wojciech

doi:10.1186/s12940-020-00580-3

Environmental Health

Table 6 The association between parabens and parameters of ovarian reserve- categorical variable

From: Parameters of ovarian reserve in relation to urinary concentrations of parabens

		AFC			AMH			FSH			E2
	Categories	coef	95%CI	p	coef	95%CI	p	coef	95%CI	p	coef	95%CI	p
MP	Cont.	− 0.02	− 0.06;0.01	0.14	− 0.05	− 0.10;0.001	0.06	− 0.01	− 0.03;0.01	0.51	− 0.01	− 0.05;0.02	0.52
	Q2	0.03	− 0.13;0.18	0.72	0.15	−0.09;0.40	0.22	0.05	− 0.05;0.15	0.34	0.03	− 0.15;0.20	0.76
	Q3	−0.11	− 0.27;0.04	0.16	− 0.11	− 0.36;0.13	0.37	− 0.08	− 0.19;0.03	0.14	0.05	− 0.12;0.23	0.55
	Q4	−0.05	− 0.21;0.11	0.54	−0.16	− 0.41;0.09	0.20	− 0.04	− 0.14;0.07	0.50	− 0.08	− 0.25;0.10	0.39
	P for trend	0.52			0.21			0.50			0.40
EP	Cont.	−0.004	− 0.03;0.02	0.77	− 0.03	− 0.07;0.02	0.22	0.002	− 0.02;0.02	0.81	− 0.03	− 0.06;0.05	0.09
	Q2	−0.01	−0.17;0.15	0.95	−0.15	− 0.41;0.10	0.24	− 0.09	−0.20;0.02	0.12	0.04	−0.14;0.22	0.66
	Q3	0.03	−0.13;0.18	0.76	0.02	−0.23;0.26	0.91	0.01	−0.09;0.12	0.79	−0.01	−0.24;0.11	0.45
	Q4	−0.02	−0.18;0.14	0.83	−0.18	− 0.43;0.07	0.16	− 0.05	−0.15;0.06	0.39	−0.14	− 0.32;0.04	0.12
	P for trend	0.84			0.20			0.39			0.29
PP	Cont.	−0.02	−0.13;-0.01	0.04	−0.03	−0.07;0.02	0.22	0.03	0.02;0.12	0.028	−0.03	−0.06;-0.001	0.04
	Q2	−0.06	−0.22;0.04	0.14	−0.09	− 0.35;0.16	0.49	0.02	−0.08;0.01	0.09	−0.12	− 0.29;0.05	0.18
	Q3	−0.03	−0.20;-0.02	0.048	−0.01	− 0.3;0.25	0.96	0.05	0.03;0.18	0.026	−0.11	−0.20;-0.01	0.03
	Q4	−0.03	−0.18;-0.03	0.05	−0.08	− 0.33;0.17	0.54	0.02	−0.08;0.03	0.07	−0.13	− 0.31;0.04	0.13
	P for trend	0.04			0.36			0.03			0.04
iBuP	Cont.	0.02	−0.05;0.09	0.61	−0.003	−0.11;0.10	0.95	−0.02	− 0.07;0.02	0.31	− 0.02	−0.10;0.06	0.62
iBuP	>LOD	0.1	−0.07;0.27	0.24	0.03	−0.24;0.30	0.84	−0.01	−0.11;0.10	0.96	−0.13	− 0.31;0.04	0.14
BP	Cont.	0.004	−0.04;0.05	0.84	−0.05	−0.12;0.01	0.11	−0.01	− 0.04;0.02	0.49	0.005	−0.04;0.05	0.83
	Q2	−0.04	−0.19;0.12	0.64	−0.02	− 0.26;0.22	0.87	− 0.03	−0.13;0.07	0.58	−0.13	− 0.30;0.04	0.14
	Q3	0.07	−0.08;0.22	0.35	0.02	−0.23;0.26	0.89	−0.09	−0.19;0.01	0.08	0.05	−0.12;0.22	0.56
	Q4	0.01	−0.14;0.16	0.89	−0.20	−0.45;0.04	0.11	−0.01	− 0.11;0.10	0.90	− 0.08	−0.25;0.09	0.37
	P for trend	0.89			0.12			0.90			0.36

Model adjusted for: age (years), BMI (kg/m²), smoking (Yes/No) and initial infertility diagnosis. Parabens exposure in the model was based on the first urine sample
MP methyl-paraben, EP ethyl-paraben, PP propyl-paraben, BP butyl-paraben, iBuP izobuthyl-paraben
Reference groups 1. In case >LOD reference is <LOD; 2. In case Q2, Q3, Q4 reference is Q1; Cont.-continuous variable
Q1- ≤ 25 percentyl; Q2- (25–50] percentyl; Q3-(50–75] percentyl; Q4- > 75 percentyl

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