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Table 3 A summary of the studies identified by the systematic review for inclusion in the meta-analysis models (based on design, survey resolution and the demographics of fenceline communities)

From: A systematic review and meta-analysis of haematological malignancies in residents living near petrochemical facilities

Lead Author (Publication Year)

Country

Study Design

Level of Adjustment a

Survey Resolution

Petrochemical Activity

Exposed Population c

Temporal

Spatial

Source of Exposure (N) b

Proximity to Source (km)

Count (N)

Mean Age (Years)

Male (%)

Cases (N) d

UP

MID

DWN

LK

MM

HL

NHL

Axelsson (2010) [6]

Sweden

Cohort

Low

1994–2005

Local

–

–

4

≤ 2

2800 (b)

0 to 65+

50 (b)

10

–

–

–

Barregard (2009) [68]

Sweden

Cohort

Low

1975–2004

Local

1

–

–

≤ 5

5000

0 to 65+

50 (b)

33

–

–

–

Beale (2010) [69]

USA

Cohort

Moderate

1973–2006

Local

5

–

–

≤ 2.5

27,100 (b)

0 to 65+

100

145

52

34

184

Beale (2010) [69]

USA

Cohort

Moderate

1973–2006

Local

5

–

–

≤ 2.5

26,900 (b)

0 to 65+

0

100

35

30

141

Bulat (2011) [56]

Serbia

Cohort

Low

2003–2008

Local

1

–

2

≤ 7.5

26,375 (a)

41 (a)

100

15

–

12

21

Bulat (2011) [56]

Serbia

Cohort

Low

2003–2008

Local

1

–

2

≤ 7.5

39,828 (a)

41 (a)

0

15

–

7

14

De Roos (2010) [70]

USA

Case-Control

High

1988–2000

Subnational

15

–

33

≤ 3.2

864

58

53

–

–

–

94

Fazzo (2016) [48]

Italy

Cohort

Low

1999–2006

Local

2

–

1

≤ 3

101

0 to 65+

100

8

4

4

4

Fazzo (2016) [48]

Italy

Cohort

Low

1999–2006

Local

2

–

1

≤ 3

37

0 to 65+

0

1

4

3

5

García-Pérez (2015) [71]

Spain

Case-Control

Moderate

1990–2011

National

–

–

96

≤ 2.5

872

<  15

58

44

–

–

–

Linos (1991) [72]

USA

Case-Control

High

1980–1983

Subnational

29

–

–

≤ 3.2

33

<  65

100

15

–

–

14

Linos (1991) [72]

USA

Case-Control

High

1980–1983

Subnational

–

–

28

≤ 3.2

59

<  65

100

27

–

–

18

Lyons (1995) [54]

UK

Cohort

Low

1974–1991

Local

–

–

1

≤ 1.5

2632

<  25

53 (b)

–

–

2

–

Pasetto (2012) [73]

Italy

Cohort

Moderate

1960–2000

Local

1

–

–

≤ 5

2419

53

100

–

–

–

11

Pekkanen (1995) [55]

Finland

Cohort

Low

1983–1986

Local

1

–

–

≤ 8

1250

0 to 65+

51

2

–

–

–

Salerno (2013) [74]

Italy

Cohort

Low

2003–2009

Local

1

–

–

≤ 3

3360 (b)

0 to 65+

100

6

2

1

10

Salerno (2013) [74]

Italy

Cohort

Low

2003–2009

Local

1

–

–

≤ 3

3160 (b)

0 to 65+

0

6

6

1

10

Sans (1995) [67]

UK

Cohort

Moderate

1974–1984

Local

1

–

–

≤ 7.5

23,650

<  15

51

119

–

–

–

Wilkinson (1999) [75]

UK

Cohort

Low

1974–1991

National

11

–

–

≤ 2

7070 (b)

<  15

51 (b)

19

–

2

4

Yu (2006) [76]

Taiwan

Case-Control

High

1997–2003

Local

4

–

5

≤ 3

25

20–29

53

14

–

–

–

Zusman (2012) [57]

Israel

Cohort

Low

2000–2006

Local

1

1

1

≤ 0.5

14,050

30–64 (a)

48 (a)

–

–

–

9

All Studies

–

–

–

–

–

–

–

–

–

187,585

–

–

579

103

96

539

  1. aLEVEL OF ADJUSTMENT | Low Typically adjusted for age and gender only, Moderate Adjusted for age, gender and at least one other demographic characteristic (i.e. income, ethnicity, or occupation); High Additionally adjusted for at least one lifestyle or genetic risk factor (i.e. BMI, smoking status, or family history)
  2. bSOURCE OF EXPOSURE | UP Upstream (‘Refineries’), MID Midstream (‘Petrochemical Storage Facilities’), DWN Downstream (‘Petrochemical Plants’ and the ‘Organic Chemical Industry’)
  3. cEXPOSED POPULATION | (a) = Author correspondence; (b) Estimated from the 1991 UK census, or the Global Rural-Urban Mapping Projects 30 arc-second grids (GRUMP v1, 2000)
  4. dCASES | LK Leukaemia, MM Multiple Myeloma, HL Hodgkin Lymphoma, NHL Non-Hodgkin Lymphoma