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Table 4 Association between clusters with high endotoxin and asthma, wheeze, and sensitization to inhalant allergens in all participants, NHANES 2005–2006

From: Endotoxin clustering with allergens in house dust and asthma outcomes in a U.S. national study

ClustersCurrent asthmaWheeze in past 12 monthsSensitization to inhalant allergens
OR (95% CI)PPinteractionOR (95% CI)PPinteractionOR (95% CI)PPinteraction
Cluster 2versus1
In all participants1.42 (1.06, 1.91)0.02 1.32 (1.07, 1.63)0.01 1.10 (0.89, 1.34)0.37 
By age
  In children1.06 (0.62, 1.81)0.830.250.98 (0.70, 1.36)0.900.0020.70 (0.42, 1.17)0.170.009
  In adults1.53 (1.06, 2.20)0.021.43 (1.15, 1.78)0.0011.19 (0.95, 1.50)0.13
By sensitization status
  Sensitized1.15 (0.83, 1.57)0.400.211.52 (1.09, 2.13)0.010.49   
  Non-sensitized1.82 (0.97, 3.43)0.061.24 (0.86, 1.81)0.25   
By exposure to ETS
  Exposed to ETS1.50 (0.79, 2.84)0.211.001.54 (0.94, 2.50)0.0850.350.99 (0.54, 1.82)0.980.48
  Non-exposed to ETS1.41 (0.99, 2.00)0.061.28 (1.05, 1.57)0.011.12 (0.95, 1.31)0.16
Cluster 3versus1
In all participants1.05 (0.76, 1.44)0.78 1.01 (0.82, 1.24)0.92 0.99 (0.86, 1.14)0.85 
By age
  In children1.10 (0.69, 1.76)0.690.950.99 (0.69, 1.41)0.940.560.69 (0.44, 1.06)0.090.02
  In adults0.98 (0.66, 1.46)0.931.01 (0.79, 1.28)0.941.07 (0.94, 1.22)0.32
By sensitization status
  Sensitized1.11 (0.80, 1.55)0.520.831.42 (1.06, 1.91)0.020.02   
  Non-sensitized1.03 (0.63, 1.68)0.900.81 (0.61, 1.07)0.14   
By exposure to ETS
  Exposed to ETS1.16 (0.70, 1.93)0.550.651.72 (1.14, 2.60)0.010.0030.81 (0.42, 1.59)0.550.56
  Non-exposed to ETS1.04 (0.74, 1.45)0.840.84 (0.64, 1.09)0.181.03 (0.95, 1.12)0.46
  1. Abbreviations: OR odds ratio; CI confidence interval; ETS environmental tobacco smoke. Odds ratios for the associations between the clusters and asthma and wheeze calculated using logistic regression. Models adjusted for age, gender, race/ethnicity, poverty income ratio, and ETS (except when the analysis was stratified by ETS)