Endotoxin clustering with allergens in house dust and asthma outcomes in a U.S. national study

Mendy, Angelico; Wilkerson, Jesse; Salo, Pӓivi M.; Zeldin, Darryl C.; Thorne, Peter S.

doi:10.1186/s12940-020-00585-y

Environmental Health

Table 4 Association between clusters with high endotoxin and asthma, wheeze, and sensitization to inhalant allergens in all participants, NHANES 2005–2006

From: Endotoxin clustering with allergens in house dust and asthma outcomes in a U.S. national study

Clusters	Current asthma			Wheeze in past 12 months			Sensitization to inhalant allergens
Clusters	OR (95% CI)	P	P_interaction	OR (95% CI)	P	P_interaction	OR (95% CI)	P	P_interaction
**Cluster 2versus**1
In all participants	1.42 (1.06, 1.91)	0.02		1.32 (1.07, 1.63)	0.01		1.10 (0.89, 1.34)	0.37
By age
In children	1.06 (0.62, 1.81)	0.83	0.25	0.98 (0.70, 1.36)	0.90	0.002	0.70 (0.42, 1.17)	0.17	0.009
In adults	1.53 (1.06, 2.20)	0.02	0.25	1.43 (1.15, 1.78)	0.001	0.002	1.19 (0.95, 1.50)	0.13	0.009
By sensitization status
Sensitized	1.15 (0.83, 1.57)	0.40	0.21	1.52 (1.09, 2.13)	0.01	0.49
Non-sensitized	1.82 (0.97, 3.43)	0.06	0.21	1.24 (0.86, 1.81)	0.25	0.49
By exposure to ETS
Exposed to ETS	1.50 (0.79, 2.84)	0.21	1.00	1.54 (0.94, 2.50)	0.085	0.35	0.99 (0.54, 1.82)	0.98	0.48
Non-exposed to ETS	1.41 (0.99, 2.00)	0.06	1.00	1.28 (1.05, 1.57)	0.01	0.35	1.12 (0.95, 1.31)	0.16	0.48
**Cluster 3versus**1
In all participants	1.05 (0.76, 1.44)	0.78		1.01 (0.82, 1.24)	0.92		0.99 (0.86, 1.14)	0.85
By age
In children	1.10 (0.69, 1.76)	0.69	0.95	0.99 (0.69, 1.41)	0.94	0.56	0.69 (0.44, 1.06)	0.09	0.02
In adults	0.98 (0.66, 1.46)	0.93	0.95	1.01 (0.79, 1.28)	0.94	0.56	1.07 (0.94, 1.22)	0.32	0.02
By sensitization status
Sensitized	1.11 (0.80, 1.55)	0.52	0.83	1.42 (1.06, 1.91)	0.02	0.02
Non-sensitized	1.03 (0.63, 1.68)	0.90	0.83	0.81 (0.61, 1.07)	0.14	0.02
By exposure to ETS
Exposed to ETS	1.16 (0.70, 1.93)	0.55	0.65	1.72 (1.14, 2.60)	0.01	0.003	0.81 (0.42, 1.59)	0.55	0.56
Non-exposed to ETS	1.04 (0.74, 1.45)	0.84	0.65	0.84 (0.64, 1.09)	0.18	0.003	1.03 (0.95, 1.12)	0.46	0.56

Abbreviations: OR odds ratio; CI confidence interval; ETS environmental tobacco smoke. Odds ratios for the associations between the clusters and asthma and wheeze calculated using logistic regression. Models adjusted for age, gender, race/ethnicity, poverty income ratio, and ETS (except when the analysis was stratified by ETS)

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ISSN: 1476-069X

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