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Table 5 Maternal median (25–75 percentile) urinary phthalate metabolite concentrations among offspring with or without allergic outcomes

From: Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

Outcome

n

MEP Median and 25–75 (ng/mL)

ΣMBPi + n Median and 25–75 (ng/mL)

ΣDEHPm Median and 25–75 (ng/mL)

ΣDiNPm Median and 25–75 (ng/mL)

Wheeze within the last 2 years

 Yes

123

21.9 (9.6–56.9)

39.7 (25.4–71.5)

22.3 (12.2–33.8)

9.4 (5.4–15.2)

 No

429

20.3 (9.0–51.9)

45.2 (27.0–70.0)

21.8 (13.7–32.3)

9.2 (5.4–19.1)

Self-reported asthma

 Yes

25

19.3 (12.7–67.2)

41.9 (30.2–71.5)

22.3 (13.9–33.8)

10.7 (5.1–22.3)

 No

510

21.4 (9.1–52.5)

44.5 (26.6–68.5)

21.8 (13.5–32.4)

9.2 (5.4–18.3)

Doctor-diagnosed asthma

 Yes

27

16.4 (6.8–55.5)

36.9 (18.3–74.2)

23.1 (9.3–31.9)

10.3 (4.0–22.3)

 No

503

21.8 (9.3–52.5)

44.8 (27.1–68.5)

21.9 (13.5–32.8)

9.3 (5.4–18.4)

Use of medicine for asthma/cold

 Yes

76

21.8 (10.3–66.3)

38.7 (30.0–64.2)

20.6 (9.6–32.6)

8.6 (5.0–14.1)

 No

476

20.7 (9.1–52.0)

45.2 (26.3–71.3)

22.0 (13.5–32.4)

9.4 (5.5–19.2)

Self-reported eczema

 Yes

57

16.0 (8.9–35.4)

43.5 (24.8–63.3)

9.6 (5.1–20.7)

21.5 (13.4–31.3)

 No

430

22.2 (10.2–55.5)

44.5 (27.2–68.5)

9.4 (5.5–19.0)

22.2 (13.7–33.4)

Doctor-diagnosed eczema

 Yes

32

14.4 (8.6–35.2)

43.1 (19.9–60.4)

9.6 (4.7–22.7)

20.3 (12.1–31.8)

 No

455

22.2 (9.7–55.0)

44.6 (27.2–69.2)

9.4 (5.5–18.8)

22.3 (13.8–33.2)

Use of medicine against eczema

 Yes

24

18.2 (8.57–38.8)

40.0 (23.6–62.5)

11.0 (4.7–36.1)

21.4 (13.4–32.7)

 No

366

23.7 (10.6–55.6)

44.3 (27.9–68.5)

9.7 (5.7–18.0)

22.1 (14.0–33.4)

Self-reported rhinitis

 Yes

49

17.8 (9.1–43.1)

49.9 (32.0–81.9)

25.2 (16.7–32.1)

11.2a (7.1–21.5)

 No

483

21.2 (8.9–55.0)

44.1 (26.6–68.5)

21.8 (13.5–33.0)

9.0 (5.2–18.0)

  1. Abbreviations: MEP monoethyl phthalate; ΣMBPi + n Monobutyl phthalate (i + n); ΣDiNPm sum of Di-isonyl phthalate metabolites; ΣDEHPm sum of Di-2-ethylhexyl phthalate metabolites
  2. aSignificant difference in urinary phthalate concentrations between the group that answered “yes” and the group that answered “no” (using Mann-Whitney test)