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Table 5 Maternal median (25–75 percentile) urinary phthalate metabolite concentrations among offspring with or without allergic outcomes

From: Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

OutcomenMEP Median and 25–75 (ng/mL)ΣMBPi + n Median and 25–75 (ng/mL)ΣDEHPm Median and 25–75 (ng/mL)ΣDiNPm Median and 25–75 (ng/mL)
Wheeze within the last 2 years
 Yes12321.9 (9.6–56.9)39.7 (25.4–71.5)22.3 (12.2–33.8)9.4 (5.4–15.2)
 No42920.3 (9.0–51.9)45.2 (27.0–70.0)21.8 (13.7–32.3)9.2 (5.4–19.1)
Self-reported asthma
 Yes2519.3 (12.7–67.2)41.9 (30.2–71.5)22.3 (13.9–33.8)10.7 (5.1–22.3)
 No51021.4 (9.1–52.5)44.5 (26.6–68.5)21.8 (13.5–32.4)9.2 (5.4–18.3)
Doctor-diagnosed asthma
 Yes2716.4 (6.8–55.5)36.9 (18.3–74.2)23.1 (9.3–31.9)10.3 (4.0–22.3)
 No50321.8 (9.3–52.5)44.8 (27.1–68.5)21.9 (13.5–32.8)9.3 (5.4–18.4)
Use of medicine for asthma/cold
 Yes7621.8 (10.3–66.3)38.7 (30.0–64.2)20.6 (9.6–32.6)8.6 (5.0–14.1)
 No47620.7 (9.1–52.0)45.2 (26.3–71.3)22.0 (13.5–32.4)9.4 (5.5–19.2)
Self-reported eczema
 Yes5716.0 (8.9–35.4)43.5 (24.8–63.3)9.6 (5.1–20.7)21.5 (13.4–31.3)
 No43022.2 (10.2–55.5)44.5 (27.2–68.5)9.4 (5.5–19.0)22.2 (13.7–33.4)
Doctor-diagnosed eczema
 Yes3214.4 (8.6–35.2)43.1 (19.9–60.4)9.6 (4.7–22.7)20.3 (12.1–31.8)
 No45522.2 (9.7–55.0)44.6 (27.2–69.2)9.4 (5.5–18.8)22.3 (13.8–33.2)
Use of medicine against eczema
 Yes2418.2 (8.57–38.8)40.0 (23.6–62.5)11.0 (4.7–36.1)21.4 (13.4–32.7)
 No36623.7 (10.6–55.6)44.3 (27.9–68.5)9.7 (5.7–18.0)22.1 (14.0–33.4)
Self-reported rhinitis
 Yes4917.8 (9.1–43.1)49.9 (32.0–81.9)25.2 (16.7–32.1)11.2a (7.1–21.5)
 No48321.2 (8.9–55.0)44.1 (26.6–68.5)21.8 (13.5–33.0)9.0 (5.2–18.0)
  1. Abbreviations: MEP monoethyl phthalate; ΣMBPi + n Monobutyl phthalate (i + n); ΣDiNPm sum of Di-isonyl phthalate metabolites; ΣDEHPm sum of Di-2-ethylhexyl phthalate metabolites
  2. aSignificant difference in urinary phthalate concentrations between the group that answered “yes” and the group that answered “no” (using Mann-Whitney test)