Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water

Li, Ying; Barregard, Lars; Xu, Yiyi; Scott, Kristin; Pineda, Daniela; Lindh, Christian H.; Jakobsson, Kristina; Fletcher, Tony

doi:10.1186/s12940-020-00588-9

Environmental Health

Table 3 Regression results of ln-transformed lipids versus ln-transformed PFAS among adults 20 to 60 years

From: Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water

		All (n = 1945)		Control (n = 130)		Total exposed (n = 1815)		Recently exposed (n = 1160)
		Coefficent (SE)	p	Coefficent (SE)	p	Coefficent (SE)	p	Coefficent (SE)	p
Total cholesterol	PFOS	0.013 (0.0036)	< 0.01	0.058 (0.028)	0.04	0.0091 (0.0044)	0.04	0.035 (0.0089)	< 0.01
	PFHxS	0.011 (0.0029)	< 0.01	0.051 (0.021)	0.02	0.0072 (0.0039)	0.06	0.029 (0.0080)	< 0.01
	PFOA	0.016 (0.0050)	< 0.01	0.042 (0.033)	0.2	0.011 (0.0055)	0.05	0.035 (0.0094)	< 0.01
	Sum PFAS^a	0.013 (0.0034)	< 0.01	0.075 (0.031)	0.02	0.0084 (0.0043)	0.05	0.032 (0.0086)	< 0.01
LDL	PFOS	0.017 (0.0049)	< 0.01	0.084 (0.041)	0.04	0.012 (0.0060)	0.05	0.050 (0.012)	< 0.01
	PFHxS	0.014 (0.0040)	< 0.01	0.087 (0.031)	0.01	0.0093 (0.0053)	0.08	0.043 (0.011)	< 0.01
	PFOA	0.020 (0.0068)	< 0.01	0.073 (0.048)	0.13	0.013 (0.0075)	0.09	0.047 (0.013)	< 0.01
	Sum PFAS	0.016 (0.0047)	< 0.01	0.12 (0.045)	0.01	0.011 (0.0058)	0.07	0.047 (0.012)	< 0.01
HDL	PFOS	0.013 (0.0046)	< 0.01	0.052 (0.034)	0.13	0.014 (0.0057)	0.01	0.045 (0.012)	< 0.01
	PFHxS	0.0097 (0.0038)	0.01	0.013 (0.026)	0.63	0.011 (0.0051)	0.03	0.036 (0.011)	< 0.01
	PFOA	0.019 (0.0065)	< 0.01	0.045 (0.040)	0.25	0.017 (0.0072)	0.02	0.048 (0.013)	< 0.01
	Sum PFAS	0.012 (0.0045)	0.01	0.040 (0.038)	0.29	0.013 (0.0056)	0.02	0.041 (0.012)	< 0.01
Triglyceride	PFOS	−0.0075 (0.0080)	0.35	−0.047 (0.080)	0.56	−0.021 (0.0098)	0.03	−0.039 (0.020)	0.05
	PFHxS	−0.0029 (0.0066)	0.65	−0.011 (0.061)	0.86	−0.015 (0.0086)	0.07	−0.032 (0.018)	0.08
	PFOA	− 0.011 (0.011)	0.32	− 0.058 (0.092)	0.53	−0.019 (0.012)	0.12	−0.018 (0.021)	0.39
	Sum PFAS	−0.0060 (0.0077)	0.44	−0.036 (0.088)	0.68	−0.018 (0.0095)	0.05	−0.035 (0.019)	0.07
total cholesterol/HDL ratio	PFOS	−0.00010 (0.0047)	0.98	0.0062 (0.044)	0.89	−0.0051 (0.0057)	0.37	−0.0099 (0.012)	0.40
	PFHxS	0.0011 (0.0038)	0.78	0.038 (0.033)	0.25	−0.0039 (0.0050)	0.44	−0.0072 (0.011)	0.50
	PFOA	−0.0030 (0.0065)	0.65	−0.0031 (0.050)	0.95	−0.0066 (0.0071)	0.35	−0.013 (0.012)	0.29
	Sum PFAS	0.00030 (0.0045)	0.95	0.035 (0.048)	0.47	−0.0046 (0.0055)	0.41	−0.0086 (0.011)	0.45

Note: All estimates are from regression models with ln-transformed lipids as response, ln-transformed of PFAS as the variables of interest and with additional adjusted for age, sex and BMI (in quartiles)
^aSum PFAS: Molar-weight adjusted sum of PFOS, PFHxS and PFOA

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