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Table 4 Standardized factor loadings (λ) of observed (measured) exposures (W-As, W-Mn, and B-Pb) on the latent Metals variable and of observed outcomes (diphtheria and tetanus) on the latent Antibody variable. Factor loadings are relevant to SEMs diagrammed in Fig. 2

From: Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

Variables

Overall (n = 498)

Girls (n = 246)

Boys (n = 255)

λ (95% CI)

p-value

λ (95% CI)

p-value

λ (95% CI)

p-value

Latent Metals

 Arsenic

  pregnancy

0.59 (0.52,0.66)

<.001

0.6 (0.5,0.7)

<.001

0.59 (0.5,0.69)

<.001

  toddlerhood

0.34 (0.25,0.43)

<.001

0.32 (0.19,0.46)

<.001

0.35 (0.21,0.49)

<.001

  childhood

0.43 (0.35,0.52)

<.001

0.36 (0.23,0.48)

<.001

0.5 (0.39,0.61)

<.001

 Manganese

  pregnancy

0.01 (−0.1,0.11)

0.91

−0.08 (− 0.24,0.08)

0.34

0.05 (− 0.1,0.2)

0.53

  toddlerhood

−0.24 (− 0.35,-0.14)

<.001

− 0.26 (− 0.41,-0.11)

0.001

−0.27 (− 0.41,-0.12)

<.001

  childhood

−0.18 (− 0.27,-0.08)

<.001

−0.17 (− 0.3,-0.03)

0.02

−0.19 (− 0.33,-0.05)

0.01

 Lead

  pregnancy

−0.81 (− 0.88,-0.75)

<.001

− 0.79 (− 0.88,-0.7)

<.001

−0.82 (− 0.92,-0.72)

<.001

  toddlerhood

−0.69 (− 0.77,-0.61)

<.001

−0.72 (− 0.84,-0.6)

<.001

−0.67 (− 0.77,-0.56)

<.001

  childhood

−0.71 (− 0.77,-0.64)

<.001

−0.81 (− 0.9,-0.71)

<.001

−0.63 (− 0.73,-0.53)

<.001

Latent Antibody

 Diphtheria

0.78 (0.71,0.85)

<.001

0.78 (0.71,0.85)

<.001

0.71 (0.65,0.77)

<.001

 Tetanus

0.75 (0.62,0.89)

<.001

0.75 (0.62,0.89)

<.001

0.84 (0.68,1)

<.001

  1. Note: Standardized loadings are restricted to values between 0 to 1.0, which are interpreted as correlations