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Table 5 Results for SEM estimating the direct and indirect effects of latent Metals on latent Antibody with weight-for-age (WFA) mediation as shown in Fig. 3

From: Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

 Overall (n = 498) Girls (n = 246) Boys (n = 255) 
Latent antibody β (95% CI)p-valueLatent antibody β (95% CI)p-valueLatent antibody β (95% CI)p-value
Latent metal associations
Direct effect−0.13 (− 0.25, − 0.02)0.02−0.31 (− 0.45, − 0.16)<.0010.02 (− 0.14, 0.18)0.82
 Indirect−0.01 (− 0.02, 0.01)0.29−0.003 (− 0.03, 0.02)0.76−0.004 (− 0.02, 0.01)0.53
  WFA ~ metals−0.11 (− 0.21, − 0.02)0.02−0.16 (− 0.28, − 0.03)0.02−0.07 (− 0.21, 0.07)0.33
  antibody ~ wfa0.06 (−0.04, 0.16)0.240.022 (−0.12, 0.16)0.760.06 (−0.08, 0.2)0.40
Total effect−0.14 (− 0.25, − 0.03)0.01−0.31 (− 0.45, − 0.17)0.760.02 (− 0.14, 0.17)0.86
  1. Note: Estimates are adjusted for the covariates indicating maternal education, breastfeeding duration, and child sex (overall model only)
  2. Fit indices for all models: CFI: 0.95–0.97; TLI = 0.94–0.96; RMSEA: 0.03–0.04