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Table 5 Results for SEM estimating the direct and indirect effects of latent Metals on latent Antibody with weight-for-age (WFA) mediation as shown in Fig. 3

From: Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

 

Overall (n = 498)

 

Girls (n = 246)

 

Boys (n = 255)

 

Latent antibody β (95% CI)

p-value

Latent antibody β (95% CI)

p-value

Latent antibody β (95% CI)

p-value

Latent metal associations

Direct effect

−0.13 (− 0.25, − 0.02)

0.02

−0.31 (− 0.45, − 0.16)

<.001

0.02 (− 0.14, 0.18)

0.82

 Indirect

−0.01 (− 0.02, 0.01)

0.29

−0.003 (− 0.03, 0.02)

0.76

−0.004 (− 0.02, 0.01)

0.53

  WFA ~ metals

−0.11 (− 0.21, − 0.02)

0.02

−0.16 (− 0.28, − 0.03)

0.02

−0.07 (− 0.21, 0.07)

0.33

  antibody ~ wfa

0.06 (−0.04, 0.16)

0.24

0.022 (−0.12, 0.16)

0.76

0.06 (−0.08, 0.2)

0.40

Total effect

−0.14 (− 0.25, − 0.03)

0.01

−0.31 (− 0.45, − 0.17)

0.76

0.02 (− 0.14, 0.17)

0.86

  1. Note: Estimates are adjusted for the covariates indicating maternal education, breastfeeding duration, and child sex (overall model only)
  2. Fit indices for all models: CFI: 0.95–0.97; TLI = 0.94–0.96; RMSEA: 0.03–0.04