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Table 3 OR and 95% CI for lymphoma subtypes by intensity and confidence of exposure to external (A) and internal (B) ionizing radiation

From: Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study

 

DLBCL

Follicular lymphoma

CLL

Multiple Myeloma

Hodgkin Lymphoma

Cases/Controls

OR

95%CI

Cases/Controls

OR

95%CI

Cases/Controls

OR

95%CI

Cases/Controls

OR

95%CI

Cases/Controls

OR

95%CI

(A)

 Unexposed

477/2164

1.0

–

219/2164

1.0

–

362/2164

1.0

–

260/2164

1.0

–

283/2164

1.0

–

 Ever exposed

55/255

0.9

0.69–1.29

31/255

1.1

0.77–1.72

45/255

1.2

0.82–1.65

15/255

0.5

0.31–0.93

34/255

0.8

0.50–1.13

Average probabilitya

 Possible

44/228

0.9

0.61–1.21

27/228

1.1

0.72–1.71

41/228

1.2

0.85–2.76

14/228

0.7

0.32–0.99

30/228

0.7

0.47–1.11

 Probable/ definite exposure

11/27

1.6

0.80–3.40

4/27

1.4

0.49–4.29

4/27

0.8

0.26–2.31

1/27

0.3

0.04–2.50

4/27

1.0

0.34–3.21

Average intensitya

 1–2.5 mSv

24/121

0.9

0.56–1.40

15/121

1.3

0.74–2.33

23/121

1.0

0.62–1.62

8/121

0.5

0.24–1.06

12/121

0.7

0.34–1.26

  ≥ 2.6 mSv

31/134

1.0

0.66–1.50

16/134

1.0

0.59–1.77

22/134

1.4

0.85–2.26

7/134

0.6

0.27–1.28

22/134

0.8

0.49–1.36

  ≥ 2.6 mSv probable/ definite exposure

7/13

2.3

0.90–5.84

2/13 0

1.4

.32–6.58

2/13

1.0

0.21–4.47

1/13

0.8

0.10–6.54

4/13

2.0

0.59–6.81

Duration of exposurea

  ≤ 11 years

28/131

1.0

0.62–1.46

11/131

0.8

0.41–1.48

20/131

1.1

0.69–1.90

7/131

0.6

0.28–1.24

22/131

0.6

0.39–1.07

  ≥ 12 years

27/124

1.0

0.60–1.44

20/124

1.5

0.93–2.53

25/124

1.2

0.75–1.87

8/124

0.5

0.23–1.01

12/124

1.0

0.52–1.86

Cumulative exposurea

 1.75–15.39 mSv-years

27/126

1.0

0.55–1.81

15/126

0.5

0.15–1.53

21/126

1.1

0.57–2.18

8/126

0.7

0.27–1.74

20/126

0.5

0.20–1.06

  ≥ 15.4 mSv-years

28/129

0.9

0.62–1.28

16/129

1.3

0.82–1.97

24/129

1.2

0.82–2.82

7/129

0.5

0.26–0.98

14/129

0.8

0.51–1.31

Probable/definite exposure

  ≥ 15.4 mSv-years

7/16

1.6

0.71–3.46

2/16

1.3

0.37–4.34

3/16

0.8

0.23–2.73

1/16

0.5

0.06–3.57

3/16

1.1

0.36–3.57

 

DLBCL

Follicular lymphoma

CLL

Multiple Myeloma

Hodgkin Lymphoma

Cases/Controls

OR

95%CI

Cases/Controls

OR

95%CI

Cases/Controls

OR

95%CI

Cases/Controls

OR

95%CI

Cases/Controls

OR

95%CI

(B)

 Unexposed

476/2164

1.0

 

219/2164

1.0

 

362/2164

1.0

 

260/2164

1.0

 

304/2164

1.0

 

 Ever exposed

8/54

0.6

0.28–1.28

2/54

0.5

0.11–1.93

4/54

0.8

0.37–1.75

3/54

0.5

0.15–1.58

2/54

0.1

0.03–0.64

Average intensity

 1–2.5 mSv

7/22

1.0

0.45–2.40

2/22

0.7

0.17–3.09

4/22

1.1

0.49–2.47

2/22

0.5

0.12–2.09

2/22

0.8

0.17–3.78

  ≥ 2.5 mSv

1/32

0.1

0.02–1.07

0/32

–

 

0/32

–

 

1/32

0.5

0.06–3.58

0/32

–

 

Average probability

 Possible

2/30

0.4

0.09–1.60

1/30

0.5

0.07–3.80

1/30

0.6

0.13–2.55

1/30

0.4

0.05–3.10

1/30

0.2

0.03–1.63

 Probable/definite

6/24

0.8

0.31–1.83

1/24

0.4

0.06–3.15

3/24

0.9

0.37–2.32

2/24

0.5

0.12–2.26

1/24

0.1

0.01–0.89

Duration of exposure

  ≤ 8 years

7/27

1.1

0.47–1.57

1/27

0.5

0.07–3.87

2/27

0.9

0.31–2.79

2/27

0.7

0.15–2.82

2/27

0.2

0.05–1.02

  ≥ 9 years

1/27

0.1

0.02–1.05

1/27

0.4

0.06–3.10

2/27

0.7

0.24–2.09

1/27

0.3

0.04–2.37

0/27

–

 

Cumulative exposure

 30 mSv-years

5/25

0.9

0.32–2.29

1/25

0.5

0.07–3.73

2/25

1.0

0.33–2.94

2/25

0.7

0.16–3.05

2/25

0.3

0.06–1.23

 30 mSv-years

3/29

0.4

0.12–1.31

1/29

0.4

0.06–3.19

2/29

0.7

0.23–2.01

1/29

0.3

0.04–2.20

0/29

–

 
  1. aTests for trend
  2. DLBCL: average probability = 0.144, p = 0.89; duration of exposure = −0.366, p = 0.71; average intensity with probable/definite exposure = 1.673, p = 0.09; cumulative exposure with probable/definite exposure = 1.284; p = 0.20
  3. FL: average probability = 0.768, p = 0.44; duration of exposure = 1.218, p = 0.22; average intensity with probable/definite exposure = 0.597, p = 0.55; cumulative exposure with probable/definite exposure = 1.075; p = 0.28
  4. HL test for trend average intensity with probable/definite exposure = 0.595, p = 0.55