Skip to main content

Table 5 Conditional logistic regression models to estimate the association between quintiles of PBDE and PBB-153 plasma levels expressed as ng/gr of lipids and breast cancer risk: adjusted odds ratios (ORs) and 95% confidence intervals (CIs) (N = 394)

From: Plasma concentration of brominated flame retardants and postmenopausal breast cancer risk: a nested case-control study in the French E3N cohort

ng/gr lipids in the plasmaNumber (%)
controls
Number(%) casesModel 0
OR [95% CI]
P trendModel 1
OR [95% CI]
P trendModel 2
OR [95% CI]
P trend
PBDE sum197197      
 Q139(19.80)44 (22.34)Reference0,85Reference0.82Reference0.74
  Q239(19.80)29 (14.72)0.68 [0.36–1.27] 0.56 [0.27–1.14] 0.63 [0.30–1.30] 
 Q340(20.30)39(19.80)0.90 [0.51–1.59] 0.92 [0.49–1.71] 0.90 [0.48–1.70] 
 Q439(19.80)36(18.27)0.82 [0.45–1.50] 0.77 [0.38–1.53] 0.85 [0.42–1.72] 
 Q540(20.30)49 (24.87)1.10 [0.60–2.01] 0.96 [0.48–1.91] 1.01 [0.50–2.01] 
log-PBDE sum1971970.99 [0.68–1.45]0.980.95 [0.62–1.46]0.810.96 [0.62–1.49]0.86
BDE-28        
 Q139(19.80)35 (17.77)Reference0.36Reference Reference0.64
 Q239(19.80)39(19.80)1.09 [0.58–2.02] 1.56 [0.76–3.20]0.551.48 [0.71–3.09] 
 Q340(20.30)33 (16.75)0.91 [0.48–1.74] 0.87 [0.41–1.86] 0.91 [0.42–1.96] 
 Q439(19.80)43 (21.83)1.19 [0.65–2.17] 1.22 [0.61–2.45] 1.34 [0.67–2.71] 
 Q540(20.30)47 (23.86)1.27 [0.70–2.30] 1.28 [0.65–2.50] 1.19 [0.60–2.36] 
log-BDE-28  1.05 [0.81–1.38]0.70.99 [0.74–1.34]0.97280.97 [0.71–1.33]0.85
BDE-47197197      
 Q139(19.80)41 (20.81)Reference0.95Reference0.89Reference1,00
 Q239(19.80)36(18.27)0.89 [0.49–1.61] 0.76 [0.39–1.47] 0.73 [0.37–1.44] 
 Q340(20.30)37(18.78)0.89 [0.49–1.62] 0.79 [0.40–1.53] 0.74 [0.37–1.46] 
 Q439(19.80)43 (21.83)1.04 [0.59–1.86] 0.97 [0.50–1.88] 0.98 [0.50–1.93] 
 Q540(20.30)40(20.30)0.95 [0.51–1.79] 0.89 [0.44–1.80] 0.93 [0.45–1.92] 
log-BDE-47  0.95 [0.71–1.27]0.710.92 [0.66–1.29]0.63170.94 [0.66–1.32]0.70
BDE-99197197      
 Q139(19.80)32 (16.24)Reference0.44Reference0.57Reference0.55
 Q239(19.80)38(19.29)1.23 [0.63–2.41] 1.20 [0.58–2.49] 1.25 [0.59–2.64] 
 Q340(20.30)40(20.30)1.25 [0.64–2.44] 1.27 [0.61–2.64] 1.34 [0.64–2.84] 
 Q439(19.80)46 (23.35)1.47 [0.76–2.83] 1.24 [0.60–2.58] 1.20 [0.57–2.52] 
 Q540(20.30)41 (20.81)1.27 [0.66–2.44] 1.27 [0.61–2.67] 1.33 [0.63–2.81] 
log-BDE-99  1.05 [0.79–1.41]0.731.06 [0.76–1.47]0.731.07 [0.76–1.49]0.70
BDE-100197197      
 Q139(19.80)43 (21.83)Reference0.99Reference0.88Reference0.97
 Q239(19.80)41 (20.81)0.97 [0.53–1.81] 0.85 [0.42–1.69] 0.99 [0.48–2.01] 
 Q340(20.30)29 (14.72)0.66 [0.35–1.27] 0.58 [0.27–1.24] 0.58 [0.27–1.25] 
 Q439(19.80)40(20.30)0.94 [0.52–1.72] 0.96 [0.48–1.91] 0.96 [0.48–1.93] 
 Q540(20.30)44 (22.34)1.01 [0.52–1.94] 0.87 [0.41–1.84] 0.99 [0.46–2.13] 
log-BDE-100  0.90 [0.66–1.22]0.480.86 [0.60–1.22]0.400.87 [0.61–1.25]0.46
BDE-153197197      
 Q139(19.80)48 (24.37)Reference0.85Reference0.84Reference0.87
 Q239(19.80)34 (17.26)0.68 [0.36–1.30] 0.60 [0.28–1.27] 0.62 [0.29–1.31] 
 Q340(20.30)29 (14.72)0.57 [0.30–1.09] 0.52 [0.24–1.12] 0.53 [0.25–1.17] 
 Q439(19.80)36(18.27)0.69 [0.35–1.34] 0.75 [0.34–1.63] 0.83 [0.37–1.85] 
 Q540(20.30)50 (25.38)1.00 [0.56–1.80] 0.81 [0.41–1.61] 0.80 [0.40–1.61] 
log-BDE-153  1.06 [0.64–1.76]0.830.94 [0.52–1.68]0.820.96 [0.53–1.73]0.88
BDE-154197197      
 Q139(19.80)33 (16.75)Reference0.45Reference0.75Reference0.76
 Q239(19.80)38(19.29)1.18 [0.61–2.28] 0.91 [0.43–1.92] 0.86 [0.40–1.85] 
 Q340(20.30)41 (20.81)1.26 [0.63–2.51] 1.30 [0.61–2.78] 1.35 [0.63–2.90] 
 Q439(19.80)46 (23.35)1.48 [0.74–2.97] 1.37 [0.63–2.98] 1.26 [0.58–2.77] 
 Q540(20.30)39(19.80)1.24 [0.63–2.44] 0.99 [0.46–2.11] 0.97 [0.45–2.10] 
log-BDE-154  0.99 [0.75–1.32]0.970.95 [0.69–1.31]0.770.95 [0.69–1.32]0.77
PBB-153197197      
 Q139(19.80)37(18.78)Reference0.59Reference0.80Reference0.74
 Q239(19.80)44 (22.34)1.21 [0.63–2.32] 1.25 [0.60–2.61] 1.19 [0.56–2.56] 
 Q340(20.30)41 (20.81)1.12 [0.58–2.15] 1.09 [0.52–2.30] 1.05 [0.49–2.27] 
 Q439(19.80)53 (26.90)1.41 [0.73–2.72] 1.74 [0.81–3.75] 1.83 [0.83–4.04] 
 Q540(20.30)22 (11.17)0.62 [0.30–1.28] 0.61 [0.27–1.38] 0.52 [0.22–1.23] 
log-PBB-153  1.06 [0.64–1.76]0.830.94 [0.52–1.68]0.830.96 [0.53–1.73]0.88
  1. Model 0: crude estimates;
  2. Model 1: adjusted for smoking status (never vs. ever), physical activity measured in metabolic equivalent tasks (MET)-hour/week (< 35 vs. ≥35), education (≤ 12 years, 12 to 14 years, > 14 years), personal history of benign breast disease (no vs. yes), and family history of breast cancer (none, in first-degree relatives, in extended relatives), parity and age at first full-term pregnancy (FFTP) (no children, 1 or 2 children and < 30 years old at FFTP, ≥3 children and < 30 years old at FFTP, ≥ 30 years old at FFTP), total breastfeeding duration (never, ≤6 or > 6 months), age at menarche (< 13 years vs. ≥ 13 years), current use of menopausal hormone therapy (pre-menopausal, yes, no), and use of oral contraceptives (ever vs. never), menopausal status and age at menopause (pre-menopausal, menopause before age 51, menopause at age 51 or later);
  3. Model 2: Model 1 + adherence score to the Healthy and the Western dietary patterns (above vs. below the median)