Skip to main content

Table 2 Persistent organic pollutants (POPs) in maternal serum according to pre-pregnancy use of combined oral contraceptives (COCs) and age. Data are presented as GM (95% CI), pg/ml. Levels below LOQ replaced with LOQ/2

From: Persistent organic pollutants, pre-pregnancy use of combined oral contraceptives, age, and time-to-pregnancy in the SELMA cohort

Chemical
(n = 818)
LOQ
(pg/mL)
n (%) > LOQ Total Cohort (n = 818) <  29 years old p-value* ≥ 29 years old p-value*
Non-COC user (n = 164) COC user (n = 173) Non-COC user (n = 280) COC user (n = 201)
PeCB 10 0
HCBa 10 818 (100.0) 45.12 (44.15–46.12) 39.53 (37.65–41.51) 43.79 (42.02–45.64) 0.002 46.93 (45.16–48.76) 48.84 (46.84–50.93) 0.08
α-HCH 20 1 (0.1) 10.03 (9.97–10.09) 10.14 (9.86–10.43)
β-HCH 15 315 (38.5) 11.53 (11.05–12.03) 9.97 (9.19–10.82) 10.18 (9.23–11.22) 0.89 12.42 (11.54–13.38) 13.04 (12–14.17) 0.25
γ-HCH 20 0
Oxychlordane 25 3 (0.4) 12.55 (12.49–12.6) 12.62 (12.39–12.86) 12.5 (12.5–12.5) 0.31 12.56 (12.48–12.65) 12.5 (12.5–12.5) 0.23
Transnonachlora 5 660 (80.7) 7.63 (7.28–7.99) 5.22 (4.69–5.81) 6.22 (5.68–6.81) 0.007 9.33 (8.69–10.01) 9.36 (8.56–10.24) 0.75
p,p’-DDT 15 49 (6.0) 8.15 (3.96–16.78) 8.04 (7.63–8.48) 7.98 (7.55–8.43) 0.52 8.27 (7.92–8.64) 8.22 (7.8–8.67) 0.80
p,p’-DDEa 40 816 (99.8) 184.68 (176.15–193.63) 152.19 (136.16–170.11) 172.73 (155.62–191.72) 0.03 198.45 (183.23–214.93) 207.26 (190.11–225.96) 0.33
PCB 74a 5 605 (74.0) 6.29 (6–6.59) 4.76 (4.28–5.3) 5.58 (5.06–6.15) 0.03 6.99 (6.5–7.52) 7.55 (6.89–8.27) 0.40
PCB 99a 5 665 (81.3) 7.27 (6.97–7.59) 5.59 (5.08–6.15) 6.6 (6.04–7.22) 0.01 8.09 (7.54–8.68) 8.45 (7.78–9.18) 0.58
PCB 118a 5 813 (99.4) 16.15 (15.61–16.72) 12.41 (11.54–13.35) 14.2 (13.23–15.24) 0.004 18.27 (17.28–19.32) 18.85 (17.68–20.1) 0.59
PCB 138a 5 818 (100.0) 72.01 (69.66–74.43) 56.67 (52.73–60.9) 64.81 (60.36–69.6) 0.02 80.98 (76.7–85.5) 81.4 (76.71–86.38) 0.93
PCB 153a 5 818 (100.0) 108.98 (105.4–112.68) 84.45 (78.45–90.92) 96.08 (89.38–103.29) 0.02 124.74 (118.26–131.59) 123.88 (116.85–131.33) 0.86
PCB 156a 5 739 (90.3) 10.97 (10.49–11.48) 7.91 (7.11–8.81) 9.19 (8.27–10.2) 0.03 13.32 (12.45–14.25) 12.74 (11.84–13.72) 0.49
PCB 170a 5 818 (100.0) 39.48 (38.04–40.97) 30.15 (27.74–32.77) 33.38 (30.74–36.26) 0.055 47.01 (44.39–49.79) 44.55 (41.82–47.46) 0.38
PCB 180a 5 818 (100.0) 75.3 (72.58–78.12) 56.73 (52.16–61.7) 62.28 (57.45–67.51) 0.08 91.3 (86.3–96.58) 85.41 (80.37–90.77) 0.20
PCB 183a 5 620 (75.8) 6.8 (6.5–7.12) 4.79 (4.35–5.28) 5.78 (5.27–6.35) 0.02 8.31 (7.72–8.95) 7.86 (7.21–8.56) 0.31
PCB 187a 5 802 (98.0) 17.76 (17.06–18.5) 13.07 (11.88–14.37) 14.53 (13.24–15.96) 0.07 21.97 (20.71–23.31) 20.17 (18.88–21.54) 0.06
PBDE 47 15 40 (5.0) 8.01 (7.84–8.19) 7.8 (7.55–8.05) 8.26 (7.78–8.77) 0.24 8 (7.69–8.32) 7.99 (7.66–8.33) 0.99
PBDE 99 15 10 (1.2) 7.62 (7.54–7.69) 7.5 (7.5–7.5) 7.72 (7.5–7.96) 0.05 7.57 (7.47–7.68) 7.69 (7.5–7.88) 0.21
PBDE 153 15 17 (2.1) 7.76 (4.64–12.98) 7.54 (7.47–7.61) 7.89 (7.59–8.2) 0.04 7.91 (7.59–8.24) 7.62 (7.39–7.86) 0.06
  1. aChemicals detected in more than 70% of the samples above the LOQ were included in further analyses
  2. *Based on Wilcoxon rank sum test
  3. Abbreviations: CI confidence interval, GM geometric mean, LOQ limit of quantification, PeCB pentachlorobenzene, HCB hexachlorobenzene, HCH hexachlorocyclohexane, p,p´-DDT dichlorodiphenyltrichloroethane, p,p´-DDE dichlorodiphenyldichloroethylene, PCB polychlorinated biphenyls, PBDE polybrominated diphenyl ether