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Table 2 Airways and non-airways stratified incidence rate ratios for determinants (including smoking) of smoking-relateda cancersb

From: Cancer rates not explained by smoking: a county-level analysis

 

All smoking-related cancers

Smoking-related cancers of the airways

Other smoking-related cancers (non–airways)

Variable

IRR

(95% CI)

IRR

(95% CI)

IRR

(95% CI)

Age at the diagnosis

 20–24

1

(Ref.)

1

(Ref.)

1

(Ref.)

 25–29

2.09

(2.00–2.18)

1.69

(1.55–1.85)

2.21

(2.11–2.32)

 30–34

4.03

(3.88–4.18)

2.99

(2.75–3.24)

4.35

(4.17–4.55)

 35–39

6.80

(6.55–7.05)

5.65

(5.238–6.09)

7.19

(6.89–7.50)

 40–44

11.98

(11.56–12.42)

12.60

(11.71–13.55)

11.86

(11.39–12.35)

 45–49

21.76

(21.01–22.53)

30.23

(28.16–32.46)

19.18

(18.43–19.97)

 50–54

39.79

(38.44–41.18)

62.32

(58.08–66.87)

32.88

(31.60–34.21)

 55–59

59.36

(57.36–61.44)

105.06

(97.93–112.72)

45.37

(43.61–47.19)

 60–64

87.73

(84.77–90.97)

162.40

(151.39–174.21)

65.05

(62.54–67.66)

 65–69

130.08

(125.70–134.61)

248.44

(231.60–266.49)

94.28

(90.65–98.06)

 70–74

170.58

(164.84–176.52)

331.66

(309.19–335.77)

122.6

(117.88–127.52)

 75–79

208.16

(201.14–215.41)

392.41

(365.81–420.95)

154.49

(148.53–160.69)

 80–84

232.11

(224.28–240.23)

405.43

(377.91–434.95)

182.83

(175.76–190.18)

Gender

Women

1

(Ref.)

1

(Ref.)

1

(Ref.)

Men

1.46

(1.45–1.46)

1.35

(1.35–1.37)

1.53

(1.52–1.54)

Year of diagnosis

 2006

1

(Ref.)

1

(Ref.)

1

(Ref.)

 2007

1.00

(0.98–1.02)

1.00

(0.97–1.03)

1.00

(0.99–1.02)

 2008

1.00

(0.98–1.02)

1.00

(0.98–1.03)

1.01

(0.99–1.02)

 2009

1.00

(0.98–1.01)

1.00

(0.98–1.03)

0.99

(0.97–1.01)

 2010

0.99

(0.97–1.00)

0.99

(0.96–1.02)

0.98

(0.96–1.00)

 2011

0.97

(0.95–0.99)

0.98

(0.95–1.00)

0.97

(0.95–0.98)

 2012

0.99

(0.97–1.01)

0.99

(0.96–1.01)

0.99

(0.97–1.00)

 2013

0.97

(0.95–0.99)

0.97

(0.94–0.99)

0.96

(0.95–0.98)

 2014

0.99

(0.97–1.01)

0.99

(0.96–1.01)

0.99

(0.98–1.01)

 2015

0.99

(0.97–1.01)

0.98

(0.96–1.01)

0.99

(0.97–1.01)

 2016

0.97

(0.95–0.99)

0.97

(0.95–1.00)

0.97

(0.95–0.99)

Prevalence of daily smoking by county

 4.5–10.0%

1

(Ref.)

1

(Ref.)

1

(Ref.)

 10.1–12.1%

1.05

(1.03–1.07)

1.09

(1.06–1.12)

1.05

(1.02–1.07)

 12.2–15.6%

1.09

(1.07–1.11)

1.20

(1.17–1.23)

1.06

(1.04–1.08)

 15.7–19.1%

1.17

(1.15–1.19)

1.36

(1.33–1.40)

1.11

(1.09–1.13)

 19.2–22.8%

1.31

(1.28–1.34)

1.62

(1.58–1.67)

1.20

(1.17–1.22)

 22.9–38.3%

1.58

(1.54–1.61)

2.19

(2.13–2.26)

1.32

(1.29–1.35)

  1. Abbreviations: CI Confidence interval; IR Incidence rate
  2. a Smoking-related cancer sites classified according to [8]
  3. b Estimates from three negative binomial regression models with random intercept on county and random slope on year. SEER 18 registries, 2006–2016, Alaska Native Tumor Registry excluded because of the lack of information on county