Skip to main content

Table 1 Summary of main results reported in mother-child cohorts addressing the relationship between prenatal urinary BPA concentrations and children’s behavior

From: Bisphenol A shapes children’s brain and behavior: towards an integrated neurotoxicity assessment including human data

Cohort study

Sample size

Prenatal urine(s) samples

Association*

Internalizing or externalizing symptoms

Boys, girls or both

HOME (USA)

Braun et al. 2009

249

3 (gestation weeks 16th and 26th, and delivery)

Yes

Externalizing at 2 yrs.

Girls

Braun et al., 2011

244

Yes

Internalizing at 3 yrs.

Braun et al., 2014

175

2 (gestation weeks 16th and 26th)

No

Autistic behaviors at 4–5 yrs.

n/a

Braun et al., 2017

178

2 (gestation weeks 16th and 26th)

Yes

Externalizing behavior trajectory throughout ages 2, 3, 4, 5 and 8

Girls

MSCEHS (USA)

Miodovnik et al., 2011

137

1 (gestation week 31th)

No

(Yes, when 6 outliers were removed from the analysis)

At 7–9 yrs.

n/a

CCCEH (USA)

Perera et al. 2012

198

1 (gestation week 34th)

Yes

Both at 3–5 yrs.

Boys

Roen et al., 2015

250

Yes

Both at 7–9 yrs.

Perera et al., 2016

241

Yes

Internalizing at 10–12 yrs.

CHAMACOS (USA)

Harley et al. 2013

292

2 (gestation weeks 14th and 26th)

Yes

Internalizing, and aggressive behavior at 7 yrs

Boys

SFFII (USA)

Evans et al., 2014

153

1 (gestation week 27th)

Yes

Both at 5 yrs.

Boys

INMA-Sabadell (Spain)

Casas et al., 2015

438

2 (1st and 3rd trimester)

Yes

Externalizing at 7 yrs.

Boys

EDEN (France)

Philippat et al., 2017

529

1 (2nd trimester)

Yes

Internalizing at 3 yrs. Externalizing at 5 yrs.

Only boys were recruited

MIREC (Canada)

Braun et al., 2017

812

1 (gestation week 12th)

Yes

Internalizing at 3 yrs.

Boys

EDC (Korea)

Lim et al., 2017

304

1 (gestation week 20th)

Yes

Externalizing (social problems) at 4 yrs.

Girls

OCC (Denmark)

Jensen et al., 2019

658

1 (gestation week 28th)

No

At 2–4 yrs.

n/a

CHECK (Korea)

Kim et al., 2018

140

1 (delivery)

No

At 1–2 yrs.

n/a

APrON (Canada)

Grohs et al., 2019

98

1 (gestation week 17th)

Yes

Internalizing at 4–5 yrs.

Both

S-MBCS (China)

Li et al., 2020

745

1 (gestation weeks 12th–16th)

Yes

Both at 2–4 yrs.

Boys

  1. For conciseness and due to space limitations, all references included in this table can be consulted in the Supplemental Table 1 of the Supplementary Appendix. *A p-value ≤ 0.05 defined the existence of an association. However, other parameters such as the internal validity of associations were also considered. n/a Not applicable, since no association was reported. APrON Alberta Pregnancy Outcomes and Nutrition, CHAMACOS Center for the Health Assessment of Mothers and Children of Salinas, CHECK Children’s Health and Environmental Chemicals in Korea, CCCEH Columbia Center for Children’s Environmental Health, EDC Environment and Development of Children, EDEN Study on the Pre- and Early Postnatal Determinants of Child Health and Development, HOME Health Outcomes and Measures of the Environment Study, INMA Environment and Childhood Project, MIREC Maternal-Infant Research on Environmental Chemicals, MSCEHS Mount Sinai Children’s Environmental Health Study, OCC Odense Child Cohort, S-MBS Shanghai-Minhang Birth Cohort Study, SFFII Study for Future Families II
Back to article page

Environmental Health

ISSN: 1476-069X