Pregnancy-induced changes in serum concentrations of perfluoroalkyl substances and the influence of kidney function

Table 4 Kidney function parameters in early and late pregnancy together with the relative changes that occurred during pregnancy

	Early		Late			Change during pregnancy, (%)
	Median	5th and 95th percentiles	Median	5th and 95th percentiles	p-value	Median	5th and 95th percentiles
Marker
Plasma creatinine (μmol/L)	57	45; 67	58	46; 72	0.004	4	−11; 23
Plasma cystatin C (mg/L)	0.63	0.55; 0.79	1.05	0.77; 1.38	< 0.001	65	26; 116
eGFR (mL/min/1.73m²)
LMrev	104	90; 120	102	86; 118	0.004	− 2	−12; 8
CKD-EPI_creatinine	119	102; 131	119	96; 130	0.003	−1	−16; 5
CAPA	136	104; 160	76	54; 108	< 0.001	−44	−59; −23
CKD-EPI_{cystatin C}	123	109; 133	76	53; 112	< 0.001	−38	− 57; −12
Mean of LMrev and CAPA	120	101; 140	89	72; 112	< 0.001	−24	−35; −13
Mean of CKD-EPI_creatinine and CKD-EPI_{cystatin C}	121	110; 130	97	78; 118	< 0.001	−20	−31; −7
eGFR_{cystatin C}/eGFR_creatinine^a
CAPA/LMrev	1.3	1.0; 1.5	0.7	0.5; 1.0	< 0.001	−40	−60; −24
CKD-EPI_{cystatin C}/CKD-EPI_creatinine	1.0	0.9; 1.1	0.7	0.5; 0.9	< 0.001	−35	−55; −13

ISSN: 1476-069X