Skip to main content

Table 6 Infant TH levels

From: Exposure to Perflouroalkyl acids and foetal and maternal thyroid status: a review

    

TSH

T3

T4

Reference

Author

Country

Year

Time point of TH measurement

Number

 

Median

Range

 

Median

Range

 

Median

Range

Normal reference range

1–7 days✦

 

TSH (mIU/L) ✦

Lower limit: 0.13–1.79

Upper limit: 9.23–57.2

 

–

–

FT4 (pmol/L) ✦

Lower limit: 8.9–20.3

Upper limit: 26.8–46.6

[38]

Kato

Japan

2016

4–7 days postpartum (heelprick)

392

TSH (mIU/L)*

2.2

LOD–7.9 a

   

FT4 (pmol/L) *, d

26.1

17.9–37.2 a

[39]

Preston

USA

2018

3 days postpartum (heel prick)

480

      

TT4 (nmol/L)*

222.7

47.6–459.5

[44]

Wang

Taiwan

2014

At delivery (cord blood serum)

92–116

TSH (mIU/L)*

6.65

 

TT3 (nmol/L)*

0.77

 

TT4 (nmol/L)*

107.7

 

FT4 (pmol/L)*

9.40

 

[46]

Yang

China

2016

At delivery (cord blood serum)

146–157

TSH (mIU/L)*

9.44

1.26–57.01

TT3 (nmol/L)

0.90

0.56–3.16

TT4 (nmol/L)

129.70

69.52–232.20

FT3 (pmol/L)

2.01

1.11–4.45

FT4 (pmol/L)

15.88

9.44–21.26

[47]

Xiao

Faroe Island

2019

At delivery (cord blood serum)

153

TSH (mIU/L)*, e

6.98b

2.03–27.40

FT3 (pmol/L)

2.35b

2.00–5.54

T4 (nmol/L)

129.07b

68.00–205.00

T3RU

0.83b

0.54–1.05

FT4 (pmol/L)

11.93b

0.38–16.60

   

FT4I (IU/L)

107.60b

65.00–191.00

[48]

Dufour

Belgium

2018

3 days postpartum (heel prick)

214

TSH (mIU/L)

4.85

Max: 16.6

      

[49]

Shah-Kulkarni

Korea

2016

At delivery (cord blood serum)

279

TSH (mIU/L)*

8.3

1.2–49.6

TT3 (nmol/L)*

0.88

0.59–2.22

TT4 (nmol/L)*

108.1

61.8–168.6

[50]

De Cock

Netherland

2014

4–7 days postpartum (heel prick)

Boys: 52

      

TT4 (nmol/L)

85.6

42–138

Girls: 31

      

TT4 (nmol/L)

89.6

68–117

[51]

Tsai

Taiwan

2017

At delivery (cord blood plasma)

118

TSH (mIU/L)*

2.92 c

0.008–14.1

TT3 (nmol/L)*

0.46c

76.3–202.8

TT4 (nmol/L)*

115.6 c

164.8–1530.5

FT3 (pmol/L)*

2.29 c

1.54–5.7

FT4 (pmol/L)*

15.4 c

10.3–29.6

[52]

Aimuzi

China

2019

At delivery (cord blood serum)

568

TSH (mIU/L)

4.66

1.73–28.87

FT3 (pmol/L)

2.03

< LOD-4.29

FT4 (pmol/L)

13.48

< LOD-18.44

  1. TT3 (total triiodothyronine), FT3 (free triiodothyronine), TT4 (total thyroxine), FT4 (free thyroxine), FT4I (free thyroxine index); T3RU (Free triiodothyronine resin uptake), ✦: Correct to Onsesveren et al 2017; https://doi.org/10.21820/23987073.2017.6.22 based on review of 35 studies of TSH and FT4 in childhood, *: Converted values, for TSH all values are converted to mIU/L, for TT3 and TT4 all values are converted to nmol/L, for FT3 and FT4 all values are converted to pmol/L, a: 95% confidence interval,b: Geometric mean, c: Mean, d: In the article the value reported were 2.03 ng/mL, converted to pmol/L giving 2613 pmol/L; other FT4 values from the same cohort (Minatoya et al. 2017) have reported similar values in ng/dL. We believe that the correct unit is 2.03 ng/dL (=26.1 pmol/L), which gives more normal FT4 levels, e: Values were reported as IU/L, we choose to interpret the values as μIU/mL / mIU/L as the values are then in the normal range and comparable with values reported from other studies