Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

Pitter, Gisella; Zare Jeddi, Maryam; Barbieri, Giulia; Gion, Massimo; Fabricio, Aline S. C.; Daprà, Francesca; Russo, Francesca; Fletcher, Tony; Canova, Cristina

doi:10.1186/s12940-020-00656-0

Table 2 Association between PFAS (ln ng/mL) and systolic and diastolic blood pressure (mmHg from GAM models (n = 15′380), adjusted by several covariates: β coefficients and 95% Confidence Intervals (CI)

From: Perfluoroalkyl substances are associated with elevated blood pressure and hypertension in highly exposed young adults

PFAS	Systolic Blood Pressure						Diastolic Blood Pressure
	Total		Males		Females		Total		Males		Females
	β	CI 95%	β	CI 95%	β	CI 95%	β	CI 95%	β	CI 95%	β	CI 95%
ln_PFOA	0.37	0.19–0.54	0.46	0.19–0.73	0.31	0.08–0.55	0.34	0.21–0.47	0.23	0.04–0.42	0.39	0.21–0.57
IQ	113.81		122.08		113.09		73.27		77.4		72.38
II Q	0.26	−0.29 - 0.81	0.12	−0.87 - 1.1	0.46	−0.2 - 1.13	0.24	−0.16 - 0.64	−0.31	−1 - 0.38	0.44	−0.06 - 0.94
III Q	0.74	0.16–1.31	0.8	−0.15 - 1.75	0.8	0.06–1.53	0.78	0.36–1.2	0.4	− 0.27 - 1.07	0.74	0.19–1.3
IV Q	1.07	0.46–1.68	1.25	0.32–2.18	0.71	− 0.2 - 1.62	0.97	0.53–1.42	0.49	− 0.17 - 1.14	1.15	0.46–1.83
ln_PFOS	0.57	0.24–0.9	0.98	0.47–1.48	0.32	−0.13 - 0.77	0.44	0.2–0.68	0.29	− 0.07 - 0.64	0.51	0.17–0.84
IQ	114.15		122.21		114.34		73.51		77.51		72.67
II Q	−0.01	−0.56 - 0.53	0.46	−0.55 - 1.47	− 0.07	−0.72 - 0.58	0.32	−0.08 - 0.72	0.3	−0.41 - 1.01	0.24	−0.24 - 0.73
III Q	0.27	−0.29 - 0.84	0.79	−0.18 - 1.76	0.26	−0.47 - 0.98	0.3	−0.12 - 0.71	0.12	−0.57 - 0.8	0.26	−0.29 - 0.8
IV Q	0.6	0–1.21	1.13	0.16–2.09	0.42	−0.45 - 1.29	0.57	0.13–1.02	0.19	−0.49 - 0.87	1.00	0.34–1.66
ln_PFHxS	0.37	0.15–0.58	0.61	0.3–0.93	0.17	− 0.13 - 0.47	0.33	0.17–0.48	0.29	0.07–0.51	0.26	0.04–0.49
IQ	113.983		121.71		113.4		73.37		77.03		72.65
II Q	−0.01	−0.56 - 0.54	0.63	−0.43 - 1.69	− 0.14	−0.78 - 0.51	0.2	−0.2 - 0.6	0.49	−0.25 - 1.24	0.04	−0.44 - 0.52
III Q	0.61	0.04–1.18	1.16	0.14–2.17	0.57	−0.14 - 1.28	0.7	0.28–1.11	0.74	0.03–1.46	0.57	0.03–1.11
IV Q	0.93	0.3–1.57	1.54	0.55–2.53	0.43	−0.61 - 1.46	0.78	0.32–1.25	0.75	0.05–1.45	0.75	−0.03 - 1.53
ln_PFNA	0.99	0.47–1.51	1.46	0.72–2.19	0.54	−0.21 - 1.28	0.62	0.24–1	0.36	− 0.16 - 0.88	0.81	0.25–1.37

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