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Table 5 Multivariable-adjusted associations between Blood Pressure (BP) Levels and their top biomarker predictors identified in Partial Least Squares analysis (PLS)

From: Immune biomarkers link air pollution exposure to blood pressure in adolescents

  Systolic BP (mmHg) Diastolic BP (mmHg)
Biomarker* Effect size (5–95% CI) P value Effect size (5–95% CI) P value
SCF, per + 40 MFI 3.30 (0.86 to 5.74) 0.0087* 0.12 (−1.75 to 1.98) 0.90
MIG, per doubling 6.06 (1.70 to 10.4) 0.0070* 1.97 (−1.35 to 5.29) 0.24
TRAIL, per doubling 7.26 (1.88 to 13.4) 0.0098* 1.88 (−2.50 to 6.25) 0.40
IL12P40, per + 271 MFI −0.089 (− 2.59 to 2.41) 0.94 −1.57 (−3.40 to 0.22) 0.085
% Th2 cells, per doubling 0.70 (−2.22 to 0.83) 0.37 1.35 (0.35 to 2.35) 0.0086*
% monocytes, per doubling −0.83 (−2.47 to 0.80) 0.31 1.69 (0.64 to 2.75) 0.0019*
  1. *Presented biomarkers were within the top 3 influential markers in PLS modeling for systolic or diastolic BP levels (Table S8). Effect sizes were adjusted for age, sex, BMI, race, smoking and asthma status. SCF stem cell factor, MIG monokine induced by gamma interferon, TRAIL TNF-related apoptosis-inducing ligand, MFI median fluorescence intensity. *Remained significant after correction for multiple comparison using the Wold-Bonferroni method