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Table 3 The DLNM estimates of the cumulative association

From: DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter

  Exposure window All newborns Boys Girls
IGF2
Factor1
Overall 0.11 (− 0.71, 0.94) − 0.25 (− 1.15, 0.64) 0.35 (− 1.11, 1.81)
Trimester 1 0.07 (− 0.57, 0.71) 0.25 (− 0.52, 1.01) 0.44 (− 0.79, 1.67)
Trimester 2 − 0.02 (− 0.49, 0.45) − 0.27 (− 0.79, 0.24) 0.04 (− 0.81, 0.89)
Trimester 3 0.06 (− 0.30, 0.41) − 0.23 (− 0.68, 0.21) − 0.13 (− 0.73, 0.48)
IGF2
Factor5
Overall − 0.14 (− 1.11, 0.83) 0.06 (− 1.52, 1.64) − 0.40 (− 1.83, 1.02)
Trimester 1 0.02 (− 0.77, 0.81) 0.25 (− 1.10, 1.60) − 0.55 (− 1.75, 0.65)
Trimester 2 0.03 (− 0.55, 0.61) − 0.06 (− 1.02, 0.90) 0.24 (− 0.60, 1.09)
Trimester 3 − 0.19 (− 0.61, 0.24) −0.13 (− 0.93, 0.67) −0.09 (− 0.69, 0.51)
H19
Factor2
Overall −0.54 (− 1.29, 0.20) −0.29 (− 1.47, 0.89) −0.34 (− 1.42, 0.74)
Trimester 1 0.07 (−0.54, 0.68) − 0.15 (− 1.15, 0.86) 0.46 (− 0.45, 1.37)
Trimester 2 −0.16 (− 0.60, 0.29) −0.08 (− 0.80, 0.64) −0.07 (− 0.73, 0.59)
Trimester 3 −0.46 (− 0.79, − 0.13) −0.06 (− 0.71, 0.58) −0.73 (− 1.20, − 0.26)
H19
Factor5
Overall 0.61 (−1.19, 1.42) 0.87 (− 0.53, 2.27) 0.23 (− 1.02, 1.48)
Trimester 1 0.70 (0.05, 1.35) 0.71 (−0.48, 1.90) 0.56 (− 0.49, 1.61)
Trimester 2 −0.11 (− 0.58, 0.36) −0.07 (− 0.92, 0.78) −0.22 (− 0.98, 0.54)
Trimester 3 0.02 (−0.33, 0.37) 0.23 (− 0.47, 0.94) −0.11 (− 0.66, 0.43)
  1. The cumulative effect of a 5 μg/m3 increase in PM2.5 concentration on IGF2 Factor1 and Factor5 and H19 Factor2 and Factor5 over different exposure windows. Estimated in all observations (n = 189), in boys (n = 98) and in girls (n = 91), respectively. Confidence intervals are shown with lower and upper bounds. Confidence level for IGF2 factors in all-observation analysis is 99.36% and that of sex-specific analysis is 99.68%. Confidence level for H19 factors in all-observation analysis is 99.15% and that of sex-specific analysis is 99.57%