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Table 3 The DLNM estimates of the cumulative association

From: DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter

 

Exposure window

All newborns

Boys

Girls

IGF2

Factor1

Overall

0.11 (− 0.71, 0.94)

− 0.25 (− 1.15, 0.64)

0.35 (− 1.11, 1.81)

Trimester 1

0.07 (− 0.57, 0.71)

0.25 (− 0.52, 1.01)

0.44 (− 0.79, 1.67)

Trimester 2

− 0.02 (− 0.49, 0.45)

− 0.27 (− 0.79, 0.24)

0.04 (− 0.81, 0.89)

Trimester 3

0.06 (− 0.30, 0.41)

− 0.23 (− 0.68, 0.21)

− 0.13 (− 0.73, 0.48)

IGF2

Factor5

Overall

− 0.14 (− 1.11, 0.83)

0.06 (− 1.52, 1.64)

− 0.40 (− 1.83, 1.02)

Trimester 1

0.02 (− 0.77, 0.81)

0.25 (− 1.10, 1.60)

− 0.55 (− 1.75, 0.65)

Trimester 2

0.03 (− 0.55, 0.61)

− 0.06 (− 1.02, 0.90)

0.24 (− 0.60, 1.09)

Trimester 3

− 0.19 (− 0.61, 0.24)

−0.13 (− 0.93, 0.67)

−0.09 (− 0.69, 0.51)

H19

Factor2

Overall

−0.54 (− 1.29, 0.20)

−0.29 (− 1.47, 0.89)

−0.34 (− 1.42, 0.74)

Trimester 1

0.07 (−0.54, 0.68)

− 0.15 (− 1.15, 0.86)

0.46 (− 0.45, 1.37)

Trimester 2

−0.16 (− 0.60, 0.29)

−0.08 (− 0.80, 0.64)

−0.07 (− 0.73, 0.59)

Trimester 3

−0.46 (− 0.79, − 0.13)

−0.06 (− 0.71, 0.58)

−0.73 (− 1.20, − 0.26)

H19

Factor5

Overall

0.61 (−1.19, 1.42)

0.87 (− 0.53, 2.27)

0.23 (− 1.02, 1.48)

Trimester 1

0.70 (0.05, 1.35)

0.71 (−0.48, 1.90)

0.56 (− 0.49, 1.61)

Trimester 2

−0.11 (− 0.58, 0.36)

−0.07 (− 0.92, 0.78)

−0.22 (− 0.98, 0.54)

Trimester 3

0.02 (−0.33, 0.37)

0.23 (− 0.47, 0.94)

−0.11 (− 0.66, 0.43)

  1. The cumulative effect of a 5 μg/m3 increase in PM2.5 concentration on IGF2 Factor1 and Factor5 and H19 Factor2 and Factor5 over different exposure windows. Estimated in all observations (n = 189), in boys (n = 98) and in girls (n = 91), respectively. Confidence intervals are shown with lower and upper bounds. Confidence level for IGF2 factors in all-observation analysis is 99.36% and that of sex-specific analysis is 99.68%. Confidence level for H19 factors in all-observation analysis is 99.15% and that of sex-specific analysis is 99.57%