Fig. 4

Overall and single-exposure effects of eight PFASs on thyroid hormone concentrations in cord blood in Bayesian kernel machine regression models stratified by infant sex. a: Overall effects on T3 in boys; b: Overall effects on T3 in girls; c Single-exposure effects of each PFAS on T3, FT3, and TSH in boys; d: Single-exposure effects of each PFAS on T3, FT3, and TSH in girls. Sub-figure A and B plot the estimated change in T3 concentrations when all PFAS concentrations are fixed at specified quantiles (ranging from 0.25 to 0.75), as compared to when PFAS concentrations are fixed at the 25th percentile. Dots indicate the estimate, and vertical lines indicate the 95% credible intervals (CrI). Sub-figure C and D describe the change in hormone concentrations associated with a change in each individual PFAS from its 25th to 75th percentile, when all the other PFASs are fixed at either the 25th (red line), 50th (green line), or 75th percentile (blue line). Dots indicate the estimate, and horizontal lines indicate the 95% CrIs. All models were adjusted for maternal age at delivery, pre-pregnancy BMI, education, parity, gestational age, delivery type, maternal passive smoking during pregnancy, maternal folic acid supplement, and paternal drinking during 3 months before pregnancy