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Fig. 2 | Environmental Health

Fig. 2

From: Metabolomic signatures of the long-term exposure to air pollution and temperature

Fig. 2

Metabolic Pathways identified as enriched among the metabolites significantly associated with a Long-term exposure to PM2.5; b top 100 metabolites loading on to ICA-Factor 2; and c Long-term exposure to temperature. Pathway analysis conducted using Metaboanalyst [36] is based on both over enrichment analysis, i.e. how many significant metabolites fall within a given pathway, and pathway topology analysis, i.e. how important those metabolites are to that pathway. The figure shows the –log (natural logarithm) of the enrichment p-value on the x-axis, and the impact score on the y-axis which is based on the cumulative importance of all the significant metabolites within the pathway. The size of each bullet represents the impact value. The color of each bullet represents the significance of the enrichment. Abbreviations: PM2.5, particulate matter ≤2.5 μm; ICA, independent component analysis

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