Biochemical
|
Super-Pathway
|
Sub-Pathway
|
Beta (SE) for individual metabolites
|
P-value for individual metabolites
|
ICA_factor2 Weight
|
ICA_factor2 Rank
|
---|
Heptanoate (7:0)
|
Lipid
|
Medium Chain Fatty Acid
|
−0.209 (0.039)
|
1.87E-07
|
−0.282
|
104
|
Inosine
|
Nucleotide
|
Purine Metabolism, (Hypo)Xanthine/Inosine containing
|
−0.368 (0.083)
|
1.71E-05
|
0.892
|
1
|
Guanosine
|
Nucleotide
|
Purine Metabolism, Guanine containing
|
−0.348 (0.071)
|
2.23E-06
|
0.329
|
78
|
X - 24,970
|
Un-identified
|
–
|
0.34 (0.057)
|
1.50E-08
|
0.360
|
63
|
X - 24,431
|
Un-identified
|
–
|
0.215 (0.05)
|
2.91E-05
|
0.160
|
190
|
X - 23,636
|
Un-identified
|
–
|
0.161 (0.026)
|
5.00E-09
|
0.141
|
214
|
- These models were linear mixed-effect regression models (LMEM) with random participant-specific intercepts and simultaneously adjusted for PM2.5, NO2, O3, and temperature (multi-pollutant models) for the same exposure window
- Beta (SE) and p-values presented are from individual metabolites analysis
- All models were adjusted for age (years), body mass index (kg/m2), cigarette pack-years, alcohol intake (< or ≥ 2 drinks per day), socioeconomic status (income payment and years of education), season (warm/cold), and relative humidity
- Significant metabolites at ENT95% significance level only are presented
- ICA_factor2 rank represents the rank of the corresponding metabolite contributing to factor 2 from the independent component analysis (ICA). Higher rank (and higher weights) means higher contribution to factor 2 of the ICA. We show alongside the weights and ranks of each metabolite that contributes to factor 2 from the ICA only because it was the only significant factor
- Range of facto2- ICA rank is from 1 to 1158 i.e., number of examined metabolites. Range of facto2- ICA weight is from −1 to 1
- The metabolites with an X-XXXX format are unknown (to date Metabolon has not been able to name the metabolite) but reproducible (Metabolon is reliably able to characterize this metabolite in multiple samples and studies)
- Abbreviations: ENT Effective/independent number of tests, PM2.5 Particulate matter ≤2.5 μm, NO2 Nitrogen dioxide, and O3 Ozone, ICA Independent component analysis, SE Standard error, NS Not significant at the ENT95% level