Fig. 4
From: Prenatal metal mixtures and child blood pressure in the Rhea mother-child cohort in Greece
BVCKMR Estimated Bivariate Exposure-Response Functions for Molybdenum and Lead. For each panel, the top row shows the exposure-response function for metal 1 setting metal 2 to its 25th percentile, while the bottom row shows the exposure-response function for metal 1 setting metal 2 to its 75th percentile (with all other metals set to their median). The column on the left shows the exposure-response function for the baseline (age 4) blood pressure measure, while the column on the right shows the exposure-response function for the per-year change in the blood pressure measure. Panel (a) shows the molybdenum-systolic blood pressure relationship by lead level, panel (b) shows the molybdenum-diastolic blood pressure relationships by lead level, panel (c) shows the lead-systolic blood pressure relationship by molybdenum level, and panel (d) shows the lead-diastolic blood pressure relationship by molybdenum level. Molybdenum and lead were log2-transformed, mean-centered, and scaled. Models were adjusted for maternal age, maternal education, maternal pre-pregnancy BMI, maternal smoking during pregnancy, child’s sex, child’s age, and child’s height. Abbreviations used: DBP, diastolic blood pressure; Mo, molybdenum; Pb, lead; SBP, systolic blood pressure