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Table 4 Summary of the effect of BPA or E2 on neutrophil functions

From: Sex-dependent dysregulation of human neutrophil responses by bisphenol A

Function Test Tested substance
BPA (16 nM) BPA (1.6 μM) E2 (100 pM)
Women Men Women Men Women Men
Chemotaxis Boyden chamber ↓ ↓ ↓ ↓ ↔ ↔
Phagocytosis Park’s method with latex (%) ↔ ↔ ↔ ↔ ↔ ↔
Phagocytosis Park’s method with latex (SCORE) ↔ ↔ ↑ ↓ ↔ ↔
NADPH oxidase activity Park’s test with NBT/NBT spontaneous ↔ ↔ ↔ ↑ ↔ ↔
NADPH oxidase activity Park’s test with NBT/NBT stimulated ↑ ↔ ↑ ↔ ↑ ↔
NETs Fluorescence microscopy ↑ ↑ ↑ ↑ ↔ ↔
CD284 (TLR4) Flow cytometry ↑ ↑ ↑ ↑ ↔ ↔
CD14 Flow cytometry ↑ ↑ ↔ ↔ ↔ ↔
NO Griess reaction ↑ ↑ ↑ ↑ ↑ ↑
  1. Legend: ↑—increase, ↓—decrease, ↔—no statistical change. Abbreviations: BPA bisphenol A, E2 17β-estradiol, NETs neutrophil extracellular traps, NO nitric oxide, NBT nitroblue tetrazolium, SCORE Social Cohesion and Reconciliation
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Environmental Health

ISSN: 1476-069X