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Table 3 Associations of noise exposure, genetic models and lifestyles with risk of NIHL

From: Associations of noise kurtosis, genetic variations in NOX3 and lifestyle factors with noise-induced hearing loss

  

Unadjusted OR (95%CI)

Unadjusted P

Adjusted OR (95% CI)

Adjusted P

Kurtosis

Complex noise/Steady noise

1.753 (1.209–2.540)

0.003

1.806 (1.235–2.643)

0.002

CNEa

≥85/<85

0.845 (0.478–1.494)

0.562

0.808 (0.454–1.437)

0.468

rs12195525

 Additive

GT/GG

0.628 (0.395–0.996)

0.048

0.618 (0.388–0.985)

0.043

TT/GG

0.777 (0.234–2.578)

0.680

0.655 (0.192–2.227)

0.498

 Dominant

TT + GT/GG

0.643 (0.415–0.997)

0.048

0.622 (0.400–0.969)

0.036

 Recessive

TT/GG + GT

0.831 (0.251–2.751)

0.761

0.700 (0.206–2.378)

0.568

 Allele

T/G

0.708 (0.476–1.054)

0.089

0.686 (0.460–1.025)

0.066

 Smoking

Yes/No

1.388 (1.010–1.907)

0.043

1.486 (1.021–2.161)

0.038

 Drinking

Yes/No

1.269 (0.894–1.802)

0.182

1.273 (0.869–1.865)

0.215

 Sleeping time

21:00~23:00/~ 21:00

1.009 (0.498–2.046)

0.980

1.017 (0.495–2.090)

0.963

23:00~/~ 21:00

0.709 (0.328–1.535)

0.383

0.760 (0.344–1.676)

0.496

 Sleeping duration

≥8 h/<8 h

1.043 (0.752–1.445)

0.803

1.150 (0.818–1.615)

0.422

 Video volume

High/Low

1.681 (1.156–2.444)

0.007

1.611 (1.101–2.358)

0.014

 Fruits/vegetables

Inadequate/Adequate

1.198 (0.852–1.685)

0.298

1.283 (0.906–1.818)

0.161

 Physical exercise

Regular/Never

0.636 (0.452–0.896)

0.010

0.598 (0.419–0.852)

0.004

 Life pressure

High/Low

1.316 (0.903–1.916)

0.153

1.253 (0.855–1.836)

0.248

 Working pressure

High/Low

1.387 (0.919–2.092)

0.119

1.341 (0.883–2.036)

0.169

 HPDs

No/Yes

1.316 (0.958–1.807)

0.090

1.330 (0.959–1.846)

0.087

  1. Adjusted for gender, age, education and working years.
  2. aAdjusted for gender, age and education.
  3. P value <0.05 was considered statistically significant and maintains significance using the Benjamini-Hochberg procedure with the false discovery rate at 0.15