Associations of noise kurtosis, genetic variations in NOX3 and lifestyle factors with noise-induced hearing loss

Table 4 Interaction between noise kurtosis and lifestyles for the risk of NIHL

Lifestyles	Steady noise (β < 10)		Complex noise (β ≥ 10)		OR (95% CI) for complex noise within strata of lifestyles	RERI (95%CI)	P value
Lifestyles	NIHL/Control (n)	OR (95%CI)	NIHL/Control (n)	OR (95%CI)	OR (95% CI) for complex noise within strata of lifestyles	RERI (95%CI)	P value
Smoking						0.891(−0.086–1.868)	0.074
No	31/49		119/126
		1		1.458 (0.863–2.464)	1.458 (0.863–2.464)
				P = 0.159	P = 0.159
Yes	30/44		127/88
		1.077 (0.554–2.095)		2.425 (1.393–4.221)	2.175 (1.244–3.805)
		P = 0.827		P = 0.002	P = 0.006
OR (95% CI) for smoking within strata of kurtosis		1.077 (0.554–2.095)		1.585 (1.012–2.484)
OR (95% CI) for smoking within strata of kurtosis		P = 0.827		P = 0.044
Video volume						1.088 (0.444–1.732)	< 0.001
Low	15/21		45/68
		1		0.959 (0.446–2.064)	0.959 (0.446–2.064)
				P = 0.916	P = 0.916
High	46/72		201/146
		0.857 (0.397–1.846)		1.904 (0.944–3.837)	2.243 (1.441–3.492)
		P = 0.693		P = 0.072	P < 0.001
OR (95% CI) for high video volume within strata of kurtosis		0.857 (0.397–1.846)		1.949 (1.255–3.026)
OR (95% CI) for high video volume within strata of kurtosis		P = 0.693		P = 0.003
Physical exercise						1.054 (0.138–1.971)	0.024
Regular	15/27		68/86
		1		1.365 (0.665–2.803)	1.365 (0.665–2.803)
				P = 0.397	P = 0.397
Never	46/66		178/128
		1.238 (0.589–2.599)		2.656 (1.341–5.261)	2.242 (1.417–3.546)
		P = 0.573		P = 0.005	P = 0.001
OR (95% CI) for never physical exercise within strata of kurtosis		1.238 (0.589–2.599)		2.078 (1.368–3.157)
		P = 0.573		P = 0.001

Adjusted for gender, age, education and working years. P value <0.05 was considered statistically significant and maintains significance using the Benjamini-Hochberg procedure with the false discovery rate at 0.15

ISSN: 1476-069X