Associations of noise kurtosis, genetic variations in NOX3 and lifestyle factors with noise-induced hearing loss

Table 5 Interaction between rs12195525 polymorphism and lifestyles for the risk of NIHL

Lifestyles	Non-risk genotype (TT + GT)		Risk genotype (GG)		OR (95% CI) for risk genotype within strata of lifestyles	RERI (95%CI)	P value
Lifestyles	NIHL/Control (n)	OR (95%CI)	NIHL/Control (n)	OR (95%CI)	OR (95% CI) for risk genotype within strata of lifestyles	RERI (95%CI)	P value
Smoking						1.042 (0.318–1.765)	0.005
No	24/30		126/145
		1		1.076 (0.595–1.947)	1.076 (0.595–1.947)
				P = 0.809	P = 0.809
Yes	16/28		141/104
		0.705 (0.302–1.646)		1.822 (0.971–3.417)	2.507 (1.269–4.955)
		P = 0.418		P = 0.062	P = 0.008
OR (95% CI) for smoking within strata of genotypes		0.705 (0.302–1.646)		1.739 (1.152–2.625)
OR (95% CI) for smoking within strata of genotypes		P = 0.418		P = 0.008
Video volume						0.774 (0.020–1.527)	0.044
Low	8/13		52/76
		1		1.087 (0.418–2.821)	1.087 (0.418–2.821)
				P = 0.865	P = 0.865
High	32/45		215/173
		1.044 (0.383–2.849)		1.905 (0.766–4.734)	1.853 (1.120–3.067)
		P = 0.933		P = 0.165	P = 0.016
OR (95% CI) for high video volume within strata of genotypes		1.044 (0.383–2.849)		1.740 (1.153–2.626)
		P = 0.933		P = 0.008
Physical exercise						0.124(−1.289–1.537)	0.864
Regular	13/24		70/89
		1		1.759 (0.819–3.778)	1.759 (0.819–3.778)
				P = 0.147	P = 0.147
Never	27/34		197/160
		1.924 (0.802–4.617)		2.807 (1.349–5.843)	1.449 (0.834–2.517)
		P = 0.143		P = 0.006	P = 0.188
OR (95% CI) for never physical exercise within strata of genotypes		1.924 (0.802–4.617)		1.605 (1.091–2.361)
		P = 0.143		P = 0.016

Adjusted for gender, age, education and working years. P value <0.05 was considered statistically significant and maintains significance using the Benjamini-Hochberg procedure with the false discovery rate at 0.15

ISSN: 1476-069X