Skip to main content

Table 3 Multiple logistic regression analysis of the association between osmolality adjusted maternal BPA exposure divided into tertiles and as continuous ln-transformed and the odds ratio (OR) and 95% confidence intervals (CI 95%) of an ASD-score > 75th percentile compared to < 75th percentile (reference) and ≥ 90th percentile compared to <90th percentile (reference) in boys and girls at 2 and or 5 years of age

From: Prenatal exposure to bisphenol A and autistic- and ADHD-related symptoms in children aged 2 and5 years from the Odense Child Cohort

 

≥75th percentile

Adjusted OR (CI 95%)

≥90th percentile

Adjusted OR (CI 95%)

ASD-score 2 years

Osmolality adjusted BPA (ng/mL)

All

(N = 166/488)

Boys

(N = 97/250)

Girls

(N = 69/238)

All

(N = 98/556)

Boys

(N = 64/283)

Girls

(N = 34/273)

 1th tertile (≤0.87)

Reference

Reference

Reference

Reference

Reference

Reference

 2nd tertile

(0.88–1.96)

0.81 (0.47–1.20)

0.86 (0.47–1.59)

0.71 (0.35–1.43)

0.84 (0.47–1.48)

0.80 (0.39–1.66)

0.89 (0.35–2.27)

 3rd tertile

(≥ 1.97)

1.06 (0.70–1.68)

1.07 (0.60–1.94)

1.05 (0.54–2.31)

1.18 (0.69–2.00)

1.37 (0.70–2.68)

0.83 (0.34–2.06)

 p-trendb

0.65

0.78

0.86

0.49

0.31

0.69

 Continuous

lnBPAc

1.08 (0.94–1.24)

1.11 (0.93–1.34)

1.02 (0.83–1.25)

1.10 (0.93–1.31)

1.17 (0.94–1.45)

0.97 (0.73–1.29)

 

>75th percentile

Adjusted OR (CI 95%)

≥90th percentile

Adjusted OR (CI 95%)

ASD-score 5 years

Osmolality adjusted BPA (ng/mL)

All

(N = 86/339)

Boys

(N = 54/169)

Girls

(N = 32/170)

All

(N = 59/366)

Boys

(N = 34/189)

Girls

(N = 25/177)

 1th tertile (≤0.87)

Reference

Reference

Reference

Reference

Reference

Reference

 2nd tertile

(0.88–1.96)

1.22 (0.63–2.36)

1.02 (0.43–2.40)

1.80 (0.58–5.54)

0.86 (0.36–1.99)

0.68 (0.24–1.90)

1.96 (0.32–11.83)

 3rd tertile

(≥ 1.97)

1.80 (0.97–3.32)

1.42 (0.64–3.13)

3.17 (1.85–9.28)*

1.65 (0.78–3.49)

1.20 (0.47–2.99)

5.03 (0.97–26.08)

 p-trendb

0.06

0.37

0.03*

0.15

0.69

0.04*

 Continuous

lnBPAc

1.25 (1.03–1.52)*

1.16 (0.91–1.49)

1.48 (1.04–2.12)*

1.20 (0.94–1.53)

1.10 (0.83–1.47)

1.61 (0.96–2.69)

  1. aAnalyses adjusted for maternal education, maternal age, pre-pregnancy BMI, child age at evaluation, parity. The sex-combined analyses were additionally adjusted for child sex
  2. bTrend across tertiles tested by inserting the tertile osmolality adjusted BPA as an ordinal indicator variable (0,1,2)
  3. cBPA inserted as a continuous variable transformed by the natural logarithm
  4. * P-value < 0.05