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Table 5 Multiple logistic regression analysis of the association between osmolality adjusted maternal BPA exposure divided into tertiles and as continuous ln-transformed and the odds ratio (OR) and 95% confidence intervals (CI 95%) of an ADHD-score ≥ 75% compared to < 75% (reference) and ≥ 90th percentile compared to <90th percentile (reference) in boys and girls at 5 years of age

From: Prenatal exposure to bisphenol A and autistic- and ADHD-related symptoms in children aged 2 and5 years from the Odense Child Cohort

Osmolality adjusted BPA (ng/mL)

All chidren (N = 109/316)

Adjusteda OR (CI 95%)

Boys (N = 66/157)

Adjusteda OR (CI 95%)

Girls (N = 43/159)

Adjusteda OR (CI 95%)

ADHD-score 5 years ≥ 75th percentile

 1st tertile (≤0.87)

Reference

Reference

reference

 2nd tertile (0.88–1.96)

0.81 (0.45–1.45)

0.80 (0.37–1-73)

0.88 (0.36–2.20)

 3rd tertile (≥ 1.97)

1.09 (0.64–1.87)

1.06 (0.51–2.17)

1.29 (0.57–2.99)

 P-trendb

0.71

0.86

0.52

 Continuous lnBPAc

1.05 (0.88–1.25)

1.01 (0.80–1.26)

1.14 (0.85–1.50)

Osmolality adjusted BPA (ng/mL)

All chidren (N = 64/361)

Adjusteda OR (CI 95%)

Boys (N = 39/184)

Adjusteda OR (CI 95%)

Girls (N = 25/177)

Adjusteda OR (CI 95%)

ADHD-score 5 years ≥ 90th percentile

 1st tertile (≤0.87)

Reference

Reference

Reference

 2nd tertile (0.88–1.96)

0.92 (0.42–1.93)

0.60 (0.21–1.69)

1.78 (0.55–5.73)

 3rd tertile (≥ 1.97)

1.33 (0.68–2.61)

1.45 (0.61–3.45)

1.29 (0.46–4.64)

 p-trendb

0.37

0.32

0.56

 Continuous lnBPAc

1.17 (0.93–1.46)

1.17 (0.88–1.56)

1.25 (0.85–1.85)

  1. aAnalyses adjusted for maternal education, maternal age, pre-pregnancy BMI, child age at evaluation, parity. The sex-combined analyses were additionally adjusted for child sex
  2. bTrend across tertiles tested by inserting the tertile osmolality adjusted BPA as an ordinal indicator variable (0,1,2)
  3. cBPA inserted as a continuous variable transformed by the natural logarithm
  4. * P-value < 0.05