Table 1 Demographic and exposure traits in the sample, restricted to non-smoking children (i.e., urinary Cotinine ≤20 ng/mg)
From: Airborne Benzo[a]Pyrene may contribute to divergent Pheno-Endotypes in children
Non-atopic Control | Non-atopic Asthmatics | Atopic Control | Atopic Asthmatics | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
N = 121 Median (Interquartile Range) | N = 37 Median (Interquartile Range) | N = 14 Median (Interquartile Range) | N = 89 Median (Interquartile Range) | |||||||
Benzo[a]pyrene (ng/m3) | 3.83 (2.27, 5.45) | 11.16 (8.64, 16.00) | ** | 2.60 (1.80, 3.20) | 2.73 (1.80, 8.64) | |||||
corticoid treatment (months) | 0 (0, 0) | 20 (0, 45) | ** | 0 (0, 2) | 36 (8, 61) | † | ||||
Cotinine / creatinine (μg/g) | 7.32 (4.95, 11.63) | 7.70 (4.68, 9.91) | 7.68 (3.49, 11.28) | 6.27 (4.46, 9.37) | ||||||
15-F2t-isoP (pg/ml plasma) | 150.14 (128.02, 170.64) | 151.23 (113.31, 170.82) | 140.03 (119.69, 164.35) | 148.79 (135.29, 169.90) | ||||||
8-oxodG (nmol/mmol creatinine) | 5.87 (4.71, 7.40) | 5.25 (4.41, 7.26) | 4.17 (3.34, 6.04) | 5.38 (4.39, 6.91) | ||||||
Carbonyls (nmol/ml plasma) | 21.01 (18.47, 24.06) | 20.36 (18.06, 22.60) | 19.82 (17.44, 23.54) | 20.15 (18.02, 23.46) | ||||||
Age at first diagnosis (months) | 127‡ (26, 165) | 17 (4, 50) | 61‡ (13, 107) | 31 (6, 67) | ||||||
N | (%) | N | (%) | N | (%) | N | (%) | |||
Sex (female) | 58 | (48%) | 17 | (46%) | 6 | (43%) | 34 | (38%) | ||
BMI category (Overweight/Obese) | 10 | (8%) | 9 | (24%) | † | 2 | (14%) | 23 | (26%) | |
Lung function deficit (positive) | 0 | (0%) | 7 | (19%) | ** | 0 | (0%) | 21 | (24%) | |
Allergic rhinitis (yes) | 2 | (2%) | 3 | (8%) | 7 | (50%) | 45 | (51%) | ||
Atopic Dermatitis (Yes) | 3 | (3%) | 20 | (54%) | ** | 5 | (36%) | 32 | (36%) | |
Upper Respiratory Infection (Yes) | 0 | (0%) | 2 | (5%) | 3 | (21%) | 13 | (15%) | ||
Age group (adolescent) | 61 | (50%) | 16 | (43%) | 5 | (36%) | 47 | (53%) | ||
Maternal smoking at home (yes) | 14 | (12%) | 4 | (11%) | 4 | (29%) | 13 | (15%) | ||